Motor and sensitive axonal regrowth after multiple intercosto-lumbar neurotizations in a sheep model

Spinal Cord
R VialleM Tadié

Abstract

Experimental animal study. To evaluate motor and sensitive axonal regrowth after multiple intercosto-lumbar neurotizations in a sheep model. France. Fifteen sheep were separated into three groups. Five sheep had multiple intercosto-lumbar neurotizations and a spinal cord lesion, five sheep were neurotized without any spinal cord lesion and five sheep had a spinal cord lesion without any neurotizations. Six months after the initial surgery, histological study of the neurotized roots was performed. The length of the three rerouted intercostal nerves was sufficient in the 10 sheep to perform an intercosto-lumbar neurotization in good conditions. Eight sheep out of the 15 had postoperative complications responsible for the animal's death in five cases. Histological cross-sections of all the neurotized L2, L3 and L4 roots showed numerous myelinated regenerated axons. Dorsal root ganglions of neurotized roots showed both large and small neurons with normal nucleus and cytoplasm. The fluorescent retrograde labeling of 18 roots revealed labeled motor neurons in five cases. This study demonstrates the technical feasibility of intercosto-lumbar neurotizations in a big mammalian model. Intercostal nerve harvesting and rerouting was succes...Continue Reading

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Oct 5, 2006·Laboratory Animals·Raphaël VialleMarc Tadié

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Citations

May 17, 2012·Journal of Neurosurgery·Susan E MackinnonWilson Z Ray
Nov 30, 2013·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Yin GangHaodong Lin
Nov 1, 2018·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·S WilsonM A Howard
Jul 16, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·S WilsonM A Howard

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