Motor and somatosensory evoked potentials are well maintained in patients given dexmedetomidine during spine surgery

Anesthesiology
Endrit BalaEhab Farag

Abstract

Many commonly used anesthetic agents produce a dose-dependent amplitude reduction and latency prolongation of evoked responses, which may impair diagnosis of intraoperative spinal cord injury. Dexmedetomidine is increasingly used as an adjunct for general anesthesia. Therefore, the authors tested the hypothesis that dexmedetomidine does not have a clinically important effect on somatosensory and transcranial motor evoked responses. Thirty-seven patients were enrolled and underwent spinal surgery with instrumentation during desflurane and remifentanil anesthesia with dexmedetomidine as an anesthetic adjunct. Upper- and lower-extremity transcranial motor evoked potentials and somatosensory evoked potentials were recorded during four defined periods: baseline without dexmedetomidine; two periods with dexmedetomidine (0.3 and 0.6 ng/ml), in a randomly determined order; and a final period 1 h after drug discontinuation. The primary outcomes were amplitude and latency of P37/N20, and amplitude, area under the curve, and voltage threshold for transcranial motor evoked potential stimulation. Of the total, data from 30 patients were evaluated. Use of dexmedetomidine, as an anesthetic adjunct, did not have an effect on the latency or amp...Continue Reading

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Citations

Nov 6, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tod Sloan
Aug 9, 2011·Anesthesia and Analgesia·Keira P Mason, Jerrold Lerman
Dec 30, 2014·Journal of Neurosciences in Rural Practice·G ChaitanyaP Satishchandra
Mar 20, 2009·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Feb 5, 2014·Anesthesiology Clinics·Chris D Glover, Nicholas P Carling
Sep 17, 2013·The Journal of Thoracic and Cardiovascular Surgery·Marshall T BellT Brett Reece
Feb 18, 2016·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Jun 13, 2009·Acta Anaesthesiologica Scandinavica·M CanS Acikgoz
Mar 7, 2012·European Journal of Pain : EJP·Y BabaL Arendt-Nielsen
May 24, 2014·Paediatric Anaesthesia·Veronica O Busso, John J McAuliffe
Jun 23, 2015·Anesthesia and Analgesia·Irene RozetMonica S Vavilala
Sep 28, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Lanjun Guo, Adrian W Gelb
Sep 3, 2010·Anesthesiology·Edward J Mascha
Nov 25, 2017·Scientific Reports·Luc JoyeuxJan Deprest
Oct 27, 2018·Journal of Neurosurgical Anesthesiology·Nan LinAdrian W Gelb
Sep 29, 2020·Anesthesiology·Deepak Sharma
Sep 29, 2020·Journal of Intensive Care Medicine·Lauren K BuhlM Dustin Boone
Jul 7, 2020·Revista española de anestesiología y reanimación·E AldanaUNKNOWN Grupo de Trabajo de la Sección de Neurociencias de la Sociedad Española de Anestesiología y Reanimación (SEDAR) y la Asociac

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