Motor-Cognitive Neural Network Communication Underlies Walking Speed in Community-Dwelling Older Adults

Frontiers in Aging Neuroscience
Victoria N PooleMichael Esterman

Abstract

While walking was once thought to be a highly automated process, it requires higher-level cognition with older age. Like other cognitive tasks, it also becomes further challenged with increased cognitive load (e.g., the addition of an unrelated dual task) and often results in poorer performance (e.g., slower speed). It is not well known, however, how intrinsic neural network communication relates to walking speed, nor to this "cost" to gait performance; i.e., "dual-task cost (DTC)." The current study investigates the relationship between network connectivity, using resting-state functional MRI (rs-fMRI), and individual differences in older adult walking speed. Fifty participants (35 females; 84 ± 4.5 years) from the MOBILIZE Boston Study cohort underwent an MRI protocol and completed a gait assessment during two conditions: walking quietly at a preferred pace and while concurrently performing a serial subtraction task. Within and between neural network connectivity measures were calculated from rs-fMRI and were correlated with walking speeds and the DTC (i.e., the percent change in speed between conditions). Among the rs-fMRI correlates, faster walking was associated with increased connectivity between motor and cognitive netwo...Continue Reading

References

Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Apr 14, 1999·Gait & Posture·S E HallidayF Prince
Apr 10, 2002·Journal of the International Neuropsychological Society : JINS·Yaakov Stern
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Jul 20, 2002·Gait & Posture·Marjorie Woollacott, Anne Shumway-Cook
Oct 18, 2002·Journal of the American Geriatrics Society·Joe VergheseRichard Lipton
Oct 2, 2003·Psychology and Aging·Paul VerhaeghenJohn Cerella
Sep 18, 2004·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·John G MiltonAna Solodkin
May 6, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J Michelle KincadeMaurizio Corbetta
Oct 9, 2007·NeuroImage·A M Clare KellyMichael P Milham
Nov 22, 2007·NeuroImage·Klaus JahnThomas Brandt
Dec 7, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Galit Yogev-SeligmannNir Giladi
May 31, 2008·Journal of the American Geriatrics Society·Olivier BeauchetVéronique Dubost
Jun 19, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ihab HajjarLewis A Lipsitz
Oct 24, 2009·Neuroscience and Biobehavioral Reviews·Rachael D SeidlerDavid B Lipps
Dec 31, 2009·Journal of Geriatric Physical Therapy·Stacy Fritz, Michelle Lusardi
Nov 6, 2010·Journal of the American College of Cardiology·Jonathan AfilaloJean-François Boivin
Mar 16, 2011·Psychology and Aging·Mark B NeiderArthur F Kramer
May 3, 2011·Archives of Physical Medicine and Rehabilitation·Joe VergheseRoee Holtzer
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Jun 16, 2011·Annals of Neurology·Farzaneh A SorondLewis A Lipsitz
Aug 5, 2011·Neurobiology of Aging·Federica AgostaMassimo Filippi
Aug 4, 2012·Journal of Affective Disorders·Justine Nienke PannekoekNic J A van der Wee
Jul 12, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea L RossoCaterina Rosano
Dec 26, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gilles AllaliFrédéric Assal
Feb 14, 2014·Human Brain Mapping·Helena M BlumenJoe Verghese
Feb 18, 2014·Cerebral Cortex·Linda GeerligsMonicque M Lorist
May 9, 2014·Journal of Aging and Physical Activity·Addie MiddletonMichelle Lusardi
Aug 26, 2015·Neuroscience and Biobehavioral Reviews·Dennis HamacherLutz Schega
May 2, 2016·Neuropsychologia·Victoria N PooleMichael Esterman
Jun 1, 2016·Maturitas·Jason A CohenJessica L Zwerling
Jan 27, 2017·Journal of Movement Disorders·Kaoru Takakusaki
Apr 28, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Azizah J Jor'danLewis A Lipsitz
Jun 1, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·AmanPreet BadhwarPierre Bellec

❮ Previous
Next ❯

Citations

Oct 5, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Junhong ZhouLewis A Lipsitz
Oct 28, 2019·Aging Clinical and Experimental Research·Lucile DupuyHélène Sauzéon
Sep 22, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G PontilloM Quarantelli
Mar 28, 2021·Scandinavian Journal of Medicine & Science in Sports·Sarianna SipiläTimo Törmäkangas
Aug 29, 2021·Journal of Aging and Physical Activity·Anna TirkkonenSarianna Sipilä

❮ Previous
Next ❯

Software Mentioned

R
GaitRite
MATLAB
MOBILIZE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Applied Gerontology : the Official Journal of the Southern Gerontological Society
Maayan AgmonBasia Belza
Behavioral and Brain Functions : BBF
Eling D de Bruin, André Schmidt
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Azizah J Jor'danLewis A Lipsitz
© 2021 Meta ULC. All rights reserved