Motor cortex excitability in restless legs syndrome

Sleep Medicine
A ScaliseGian Luigi Gigli

Abstract

A review of the literature shows that the transcranial magnetic stimulation (TMS) is a useful neurophysiological tool to investigate the pathophysiology of the restless legs syndrome (RLS). In this study we used TMS to define motor cortical excitability in RLS subjects. Six RLS patients and two healthy control subjects underwent TMS (single and paired) examination using two protocols: (1) the evaluation of motor cortical excitability changes occurring at various times after a repetitive finger movement task; (2) the evaluation of the time course of intracortical motor activity tested with pairs of magnetic stimuli applied at inter-stimulus intervals of 1-6 ms. Subjects affected by RLS do not show the normal fluctuations of motor cortical excitability usually found after a bimanual finger movement task. The intracortical inhibition was reduced in RLS subjects. These results compared with the other studies suggest a modification in the central circuits and suppose a reduction or alteration in the cortical plasticity.

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Citations

May 20, 2008·CNS Drugs·Pankaj Satija, William G Ondo
Dec 20, 2007·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·A Gorsler, J Liepert
Jul 17, 2010·Journal of Neurology·Vincenzo RizzoA Quartarone
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Oct 18, 2016·Sleep Medicine·Giuseppe LanzaWalter Paulus
Mar 23, 2017·Journal of the Neurological Sciences·Joselisa Péres Queiroz de PaivaAdriana Bastos Conforto
Oct 3, 2006·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·M Barry, A L Leahy
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Feb 4, 2016·Journal of Complementary & Integrative Medicine·Ruohollah Seddigh, Amir-Abbas Keshavarz-Akhlaghi

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