Motor cortex maturation is associated with reductions in recurrent connectivity among functional subpopulations and increases in intrinsic excitability

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jeremy S BianeJames M Conner

Abstract

Behavior is derived from the configuration of synaptic connectivity among functionally diverse neurons. Fine motor behavior is absent at birth in most mammals but gradually emerges during subsequent postnatal corticospinal system maturation; the nature of circuit development and reorganization during this period has been largely unexplored. We investigated connectivity and synaptic signaling among functionally distinct corticospinal populations in Fischer 344 rats from postnatal day 18 through 75 using retrograde tracer injections into specific spinal cord segments associated with distinct aspects of forelimb function. Primary motor cortex slices were prepared enabling simultaneous patch-clamp recordings of up to four labeled corticospinal neurons and testing of 3489 potential synaptic connections. We find that, in immature animals, local connectivity is biased toward corticospinal neurons projecting to the same spinal cord segment; this within-population connectivity significantly decreases through maturation until connection frequency is similar between neurons projecting to the same (within-population) or different (across-population) spinal segments. Concomitantly, postnatal maturation is associated with a significant reduc...Continue Reading

Citations

Mar 26, 2016·Frontiers in Neuroanatomy·Yunuen Moreno-LópezGerardo Rojas-Piloni
Jul 16, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Andrew EisenMatthew C Kiernan
Jun 15, 2018·I-Perception·Franziska WeissGregor Volberg
Jun 9, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Hisham Mohammed, Edmund R Hollis
Oct 25, 2017·Frontiers in Neural Circuits·Clément Vitrac, Marianne Benoit-Marand
Feb 24, 2020·Neuroscience·Diana C RotaruYpe Elgersma
Nov 14, 2020·Nature Reviews. Neuroscience·Mary T Joy, S Thomas Carmichael

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