Motor development delay in offspring is associated with prenatal telbivudine exposure

Medicine
Chengliang ZhouHe-Feng Huang

Abstract

Telbivudine is an orally nucleoside analog with potent and specific antihepatitis B virus (HBV) activity, and it has been reported to block mother-to-infant transmission. However, few studies have focused on the safety of prenatal exposure for offspring development.This is a prospective noninterventional study. Participants were enrolled during delivery through the Women's Hospital of Zhejiang University School of Medicine between January 2012 and September 2013. Neonate's umbilical cord arterial blood (UCAB) was collected after delivery. Hepatitis B virus DNA copy, HBV serology, alanine aminotransferase (ALT), creatine kinase (CK), creatinine (CRE), and blood urea nitrogen (BUN) were measured. The development of the offspring was evaluated by the Chinese Revision of Bayley Scales of Child Development (BSCD-CR) at 12 to 24 months old.Around 30 and 31 chronic hepatitis B mothers were recruited in untreated group (non-LdT group) and telbivudine-treatment group (LdT group), respectively, and 2 children (one in non-LdT group and 1 in LdT group) were lost in follow-up. Sixty-one normal women and their children were recruited as a normal control (control group). Compared with non-LdT group, telbivudine treatment effectively blocks HB...Continue Reading

References

Nov 17, 1990·BMJ : British Medical Journal·D J Barker
Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K C Hyams
Dec 11, 1997·The New England Journal of Medicine·W M Lee
Dec 21, 2007·The New England Journal of Medicine·Ching-Lung LaiUNKNOWN Globe Study Group
May 14, 2008·Antimicrobial Agents and Chemotherapy·Edward G BridgesShouqi Luo
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan T HeijmansL H Lumey
Nov 26, 2008·Gastroenterology·Yun-Fan LiawUNKNOWN GLOBE Study Group
Jun 7, 2011·The American Journal of the Medical Sciences·Shuangsuo DangXiaoli Jia
Sep 27, 2013·Gastroenterology·Edward J GaneAldo Trylesinski
Sep 19, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·J C DunkelbergK K Leslie
Sep 25, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Quanxin WuYuming Wang
Dec 3, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Huihui ZengYing Shen
Apr 15, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yingxia LiuJia Xiao

❮ Previous
Next ❯

Citations

Jul 8, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hongyu HuangYi-Hua Zhou
Jun 13, 2019·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection
PCR

Software Mentioned

SAS

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.