Motor evoked potential polyphasia: a novel endophenotype of idiopathic generalized epilepsy

Neurology
Fahmida A ChowdhuryMark P Richardson

Abstract

We compared the motor evoked potential (MEP) phases using transcranial magnetic stimulation in patients with idiopathic generalized epilepsy (IGE), their relatives, and healthy controls, hypothesizing that patients and their unaffected relatives may share a subtle pathophysiologic abnormality. In a cross-sectional study, we investigated 23 patients with IGE, 34 first-degree relatives, and 30 matched healthy controls. Transcranial magnetic stimulation was performed to produce a series of suprathreshold single-pulse MEPs. A semiautomated method was used to count phases. We compared between groups the mean number of MEP phases, the stimulus-to-stimulus variability in MEP phases, and the proportion of polyphasic MEPs within subjects. Patients with IGE and their relatives had a significantly increased number of MEP phases (median for patients 2.24, relatives 2.17, controls 2.01) and a significantly higher proportion of MEPs with more than 2 phases than controls (median for patients 0.118, relatives 0.088, controls 0.013). Patients had a greater stimulus-to-stimulus variability in number of MEP phases than controls. There were no differences between patients and relatives. Increased MEP polyphasia in patients with IGE and their first...Continue Reading

Citations

Jan 23, 2016·Frontiers in Neuroscience·Marisa BrumJosep Valls-Solé
Jul 30, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Annika A de GoedeMichel J A M van Putten
Jan 18, 2018·Brain : a Journal of Neurology·Prisca R BauerJosemir W Sander
Feb 9, 2017·Annals of Clinical and Translational Neurology·Adam D PawleyMark P Richardson
Sep 26, 2020·Frontiers in Integrative Neuroscience·Stefani StefaniSavvas S Papacostas
Aug 21, 2020·Neurology·Joanna GescheChristoph P Beier
May 24, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Joanna GescheChristoph P Beier

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