PMID: 9536951Apr 16, 1998Paper

Motor function of the proximal stomach and visceral perception in gastro-oesophageal reflux disease

Gut
Roberto PenaginiR H Holloway

Abstract

The abnormally high postprandial rate of transient lower oesophageal sphincter relaxations seen in patients with reflux disease may be related to altered proximal gastric motor function. Heightened visceral sensitivity may also contribute to reporting of symptoms in these patients. To assess motor function of the proximal stomach and visceral perception in reflux disease with a barostat. Fasting and postprandial proximal gastric motility, sensation, and symptoms were measured in nine patients with reflux disease and nine healthy subjects. Gastric emptying of solids and liquids was assessed in six of the patients on a different day (and compared to historical controls). Minimal distending pressure and gastric compliance were similar in the two groups, whereas the patients experienced fullness at lower pressures (p < 0.05) and discomfort at lower balloon volumes (p < 0.005) during isobaric and isovolumetric distensions respectively. Maximal gastric relaxation induced by the meal was similar in the two groups. Late after the meal, however, proximal gastric tone was lower (p < 0.01) and the score for fullness higher (p < 0.01) in the reflux patients, in whom the retention of both solids and liquids in the proximal stomach was great...Continue Reading

References

Jan 27, 1990·Lancet·A G KlauserS A Müller-Lissner
Jun 1, 1990·Gut·J B WymanJ Downton
Dec 1, 1989·Appetite·C P Sepple, N W Read
Jan 1, 1988·The British Journal of Radiology·P J CollinsB E Chatterton
Jan 1, 1987·Journal of the Autonomic Nervous System·L A BlackshawT Scratcherd
May 1, 1985·The British Journal of Surgery·G J MaddernG G Jamieson
Oct 2, 1982·British Medical Journal·D J Ewing, B F Clarke
Feb 1, 1981·The Journal of Pediatrics·A C HillemeierJ Gryboski
Dec 16, 1982·The New England Journal of Medicine·W J DoddsM S Egide
Aug 1, 1995·Gastroenterology·R K MittalJ Dent
Jan 1, 1995·Gastroenterology·M N SchoemanR H Holloway
Sep 1, 1995·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G S HebbardJ Dent
Jun 1, 1996·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R PenaginiR H Holloway

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Citations

Aug 26, 2010·Pediatric Surgery International·José Estevão-CostaAna Maria Brazão
May 26, 2005·Current Gastroenterology Reports·Sara Emerenziani, Daniel Sifrim
Jul 30, 2010·Current Gastroenterology Reports·Jose M Remes-Troche
Sep 4, 2013·Best Practice & Research. Clinical Gastroenterology·Yeong Yeh Lee, Kenneth E L McColl
Jan 31, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E M Quigley, J K DiBaise
Sep 19, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J FreedmanE Näslund
Jan 9, 2013·Nature Reviews. Gastroenterology & Hepatology·Eamonn M M Quigley, Brian E Lacy
Jun 6, 2002·Alimentary Pharmacology & Therapeutics·R PenaginiP Cantu
Feb 22, 2002·Alimentary Pharmacology & Therapeutics·D P HirschG E E Boeckxstaens
Oct 26, 1999·Journal of Gastroenterology and Hepatology·M TraunerR E Stauber
Oct 7, 2006·Current Opinion in Gastroenterology·G W Falk
Jun 9, 2001·Journal of Pediatric Gastroenterology and Nutrition·J Estevão-CostaJ L Carvalho
Apr 25, 2006·Journal of Clinical Gastroenterology·Yu Kyung ChoIn-Sik Chung
Jun 5, 2007·Current Opinion in Gastroenterology·George Karamanolis, Daniel Sifrim
Aug 11, 2005·Gut·A M DrewesL Arendt-Nielsen
Dec 5, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R C H SchefferH G Gooszen
Jun 27, 2006·Journal of Gastroenterology·Toku Takahashi
Feb 24, 2001·European Journal of Gastroenterology & Hepatology·R Penagini
Aug 19, 2004·European Journal of Gastroenterology & Hepatology·Daniel Sifrim
Apr 22, 2005·Scandinavian Journal of Gastroenterology·C L ChenL C Huang
Apr 25, 2007·Scandinavian Journal of Gastroenterology·Hariprasad ReddyPeter Funch-Jensen
Feb 5, 2009·Scandinavian Journal of Gastroenterology·Rutger FrankhuisenMelvin Samsom
Dec 4, 2010·Best Practice & Research. Clinical Gastroenterology·Roberto Penagini, Ivana Bravi
Oct 5, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E BattagliaG Bassotti
Nov 4, 2004·Alimentary Pharmacology & Therapeutics·E M M Quigley
Feb 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M J MonroeE R Partosoedarso
Jun 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S CarmagnolaR Penagini
Dec 20, 2008·Acta Anaesthesiologica Scandinavica·T UmenaiE Chihara
Jan 23, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C L A BarbieriR O Dantas
May 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P IovinoC Ciacci
Jan 9, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A Sise, F K Friedenberg
Sep 12, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S GonlachanvitH P Parkman
Jul 16, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G GourcerolP Ducrotte
Jul 6, 2011·Alimentary Pharmacology & Therapeutics·K RaviD A Katzka

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