Motor impairment in children with Neurofibromatosis type 1: Effect of the comorbidity with language disorders

Brain & Development
Stéphanie IannuzziYves Chaix

Abstract

There is a body of evidence demonstrating comorbidity of motor and cognitive deficit in «idiopathic» developmental disorders. These associations are also found in developmental disorders secondary to monogenic disorders as in Neurofibromatosis type 1 for which the principal complication during childhood is learning disabilities. The comparison of motor impairment between developmental disorders either idiopathic or secondary as in NF1 could help us to better understand the cause of the combined language/motor deficit in these populations. The aim of this current study was to investigate motor impairment in children with NF1 for which oral language had been specified and then to compare the motors skills of the NF1 group to motor performance of children with Specific Language Disorder (SLD). Two groups of 49 children between 5 and 12years old were included and compared, the NF1 group and the SLD (Specific Language Disorder) group. Each child completed evaluation involving cognitive, language and motor assessment. In NF1 group, motor impairment was more frequent and more severe and concerned specifically balance rather than manual dexterity or ball skills, compared to a group of children with SLD. This motor impairment was indepe...Continue Reading

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Citations

May 26, 2017·Developmental Medicine and Child Neurology·Melanie MasoudMohamad A Mikati
Jan 11, 2018·Journal of Child Neurology·Vincent Domon-ArchambaultSébastien Perreault
Nov 23, 2017·Frontiers in Pediatrics·Martha Milade Torres NupanPaula Marcela Herrera Gomez
Aug 11, 2018·Orphanet Journal of Rare Diseases·Vivian VisnapuuJuha Peltonen

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