Motor Impairments Correlate with Social Deficits and Restricted Neuronal Loss in an Environmental Model of Autism

The International Journal of Neuropsychopharmacology
Tareq Al SagheerMohamed Jaber

Abstract

Motor impairments are amongst the earliest and most consistent signs of autism spectrum disorders but are not used as diagnostic criteria. In addition, the relationship between motor and cognitive impairments and their respective neural substrates remain unknown. Here, we aimed at determining whether a well-acknowledged animal model of autism spectrum disorders, the valproic acid model, displays motor impairments and whether they may correlate with social deficits and neuronal loss within motor brain areas. For this, pregnant female mice (C57BL/6J) received valproic acid (450 mg/kg) at embryonic day 12.5 and offspring underwent a battery of behavioral analyses before being killed for histological correlates in motor cortex, nigrostriatal pathway, and cerebellum. We show that while valproic acid male mice show both social and motor impairments, female mice only show motor impairments. Prenatal valproic acid exposure induces specific cell loss within the motor cortex and cerebellum and that is of higher magnitude in males than in females. Finally, we demonstrate that motor dysfunction correlates with reduced social behavior and that motor and social deficits both correlate with a loss of Purkinje cells within the Crus I cerebella...Continue Reading

References

Apr 1, 1994·Developmental Medicine and Child Neurology·A L ChristiansonJ G Kromberg
Dec 1, 1993·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·G Morriss-KayY Fukiishi
Jun 24, 1996·The Journal of Comparative Neurology·P M RodierJ Romano
Oct 8, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D C RogersJ E Martin
Jun 10, 1998·Brain : a Journal of Neurology·A BaileyP Lantos
Jul 7, 2000·Journal of Medical Genetics·S J MooreJ C Dean
Apr 21, 2001·Biological Psychiatry·K Pierce, E Courchesne
Jul 9, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tomasz Schneider, Ryszard Przewłocki
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sheila M FlemingMarie-Françoise Chesselet
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Tara L ArndtPatricia M Rodier
Aug 20, 2005·Developmental Medicine and Child Neurology·A D RasalamJ C S Dean
Apr 13, 2006·Journal of Autism and Developmental Disorders·George C WagnerAlycia K Halladay
May 1, 2007·Brain & Development·Xue MingGeorge C Wagner
Sep 7, 2007·Journal of Autism and Developmental Disorders·Sally OzonoffSally J Rogers
Jun 7, 2008·Brain & Development·Gianluca EspositoFilippo Muratori
Nov 6, 2008·Developmental Psychobiology·Wanda M SnowTammy L Ivanco
Jan 21, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Nurit Yirmiya, Tony Charman
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andreea C BostanPeter L Strick
Dec 7, 2010·Biological Psychiatry·Michael J GandalSteven J Siegel
Sep 13, 2011·NeuroImage·Catherine J StoodleyJeremy D Schmahmann
Nov 19, 2011·The International Journal of Neuropsychopharmacology·Shunsuke KataokaToshio Matsuda
Mar 1, 2012·The Cerebellum·S Hossein FatemiJohn P Welsh
Jul 16, 2013·Journal of Visualized Experiments : JoVE·Sheila M FlemingValentins Ghisays
Mar 4, 2014·PloS One·Jerry SkefosMargaret Bauman
Nov 25, 2014·Nature Communications·Claire PiochonChristian Hansel
Jan 23, 2015·Brain : a Journal of Neurology·Mollie K MarkoStewart H Mostofsky
Nov 7, 2015·Biological Psychiatry·Mary Beth NebelStewart H Mostofsky
Dec 18, 2015·Nature Reviews. Neuroscience·Allan V KalueffJohn C Fentress
Feb 10, 2016·Nutritional Neuroscience·Kamila CastroCarmem Gottfried
Dec 17, 2016·Neuroscience·Stacey L Main, Randy J Kulesza
May 5, 2017·Experimental Neurology·Chiara Nicolini, Margaret Fahnestock
May 27, 2017·Journal of the American Academy of Child and Adolescent Psychiatry·Rachel LoomesWilliam Polmear Locke Mandy
Jun 29, 2017·Behavioural Brain Research·Hiroshi YamaguchiKazuhiro Takuma

❮ Previous
Next ❯

Citations

Apr 2, 2019·Médecine sciences : M/S·Jean-Louis Bossu, Sébastien Roux
Jan 24, 2020·Sensors·Elizabeth B TorresSejal Mistry
Jul 7, 2020·Frontiers in Integrative Neuroscience·Carla CaballeroElizabeth B Torres
Jan 21, 2021·Molecular Autism·Emmanuel MatasMohamed Jaber
Jan 29, 2021·Frontiers in Behavioral Neuroscience·Nelva T QuezadaEsteban E Aliaga
Mar 22, 2021·Journal of Neurodevelopmental Disorders·Rachel M RahnSusan E Maloney
Nov 26, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Esraa M ElnahasSawsan Aboul-Fotouh
May 18, 2021·Current Protocols·Robert LalondeCatherine Strazielle
Aug 19, 2020·Developmental Neuroscience·Devahuti ChalihaJohn Mamo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.