Motor inhibition and cognitive flexibility in pathologic skin picking

Progress in Neuro-psychopharmacology & Biological Psychiatry
Brian L OdlaugJon E Grant

Abstract

Individuals with pathologic skin picking (PSP) often report significant difficulty resisting the urges and drive to engage in picking behavior. Studies have shown significant inhibitory deficiencies (i.e. increased impulsivity) in subjects with other putative obsessive-compulsive spectrum disorders, such as trichotillomania, using objective tests. This study sought to assess motor inhibitory control and aspects of cognitive flexibility in a sample of individuals with PSP. Twenty subjects with PSP (mean age 33.1+/-14.3 years; 85% female) and 20 healthy controls (mean age 31.6+/-9.1 years; 85% female) underwent cognitive assessments using the Stop-signal and Intra-dimensional/Extra-dimensional (ID/ED) set-shift tasks. Groups were matched for age, gender, and education. PSP was associated with significantly impaired stop-signal reaction times but intact ID/ED cognitive flexibility compared to controls. Measures of disease severity in the PSP subjects did not covary significantly with stop-signal performance. The finding of impaired inhibitory control but intact set-shift cognitive flexibility draws remarkable parallels with findings in trichotillomania but differs from obsessive compulsive disorder. These findings have important i...Continue Reading

References

Jul 1, 1986·Comprehensive Psychiatry·M A GuptaH F Haberman
Apr 15, 1996·Biological Psychiatry·N J KeuthenL Baer
Jan 4, 1998·Journal of Anxiety Disorders·M A StanleyJ K Breckenridge
Nov 18, 1998·The Journal of Clinical Psychiatry·L M ArnoldE M Morris
Feb 6, 1999·Journal of Clinical Psychopharmacology·L M ArnoldS L McElroy
Aug 25, 1999·Psychiatry and Clinical Neurosciences·R Coetzer, D J Stein
Jan 22, 2003·Nature Neuroscience·Adam R AronTrevor W Robbins
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Mar 31, 2004·Trends in Cognitive Sciences·Adam R AronRussell A Poldrack
Jun 21, 2005·Journal of Clinical and Experimental Neuropsychology·Antje BohneSabine Wilhelm
Jun 22, 2005·Drug and Alcohol Dependence·John R MonterossoEdythe D London
Nov 3, 2005·The American Journal of Psychiatry·Jon E GrantMarc N Potenza
Dec 22, 2005·Behaviour Research and Therapy·Michael P TwohigAkihiko Masuda
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam R Aron, Russell A Poldrack
May 26, 2006·Behavior Modification·Ellen J TengMichael P Twohig
Jul 4, 2006·The American Journal of Psychiatry·Samuel R ChamberlainBarbara J Sahakian
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam R AronRussell A Poldrack
Apr 7, 2007·Current Opinion in Psychiatry·Samuel R Chamberlain, Barbara J Sahakian
Jun 9, 2007·Biological Psychiatry·Samuel R ChamberlainBarbara J Sahakian
Jul 24, 2007·Biological Psychiatry·Samuel R ChamberlainBarbara J Sahakian
Oct 6, 2007·The Journal of Clinical Psychiatry·Jon E GrantSuck Won Kim
Jan 1, 2008·General Hospital Psychiatry·Brian L Odlaug, Jon E Grant
Jun 24, 2008·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Brian L Odlaug, Jon E Grant
Nov 27, 2008·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Dan J SteinDouglas W Woods
Feb 19, 2009·Journal of Anxiety Disorders·Stephania L HayesLissette Berlanga
Feb 16, 2010·Comprehensive Psychiatry·Nancy J KeuthenRichard T Serpe
Dec 8, 2010·The Journal of Nervous and Mental Disease·Christopher A FlessnerNancy J Keuthen

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Citations

Aug 15, 2012·Journal of Clinical and Experimental Neuropsychology·Désirée S AichertUlrich Ettinger
Dec 20, 2012·The Primary Care Companion to CNS Disorders·Brian L OdlaugJon E Grant
Oct 8, 2013·CNS Spectrums·Laure-Sophie Camilla d'AngeloSamuel R Chamberlain
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jon E GrantSamuel R Chamberlain
Nov 7, 2015·International Journal of Psychiatry in Clinical Practice·Eric W LeppinkJon E Grant
Nov 15, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Elisa GalimbertiLaura Bellodi
Oct 8, 2011·Journal of Behavior Therapy and Experimental Psychiatry·Kathrin SchuckMike Rinck
Aug 10, 2011·Journal of Psychiatric Research·Jon E GrantSamuel R Chamberlain
Jun 11, 2011·Behavior Therapy·Ívar SnorrasonRagnar P Ólafsson
Nov 21, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Samuel R ChamberlainJon E Grant
Jun 13, 2015·Body Image·Jon E GrantBrian L Odlaug
Nov 19, 2015·Depression and Anxiety·Christopher A FlessnerSarah Francazio
Apr 14, 2016·Neuroscience·Jessica L Hurtubise, John G Howland
Aug 1, 2013·International Journal of Psychiatry in Clinical Practice·Brian Lawrence OdlaugJon Edgar Grant
Apr 29, 2015·Psychiatry Research·Elle Brennan, Christopher Flessner
May 21, 2015·Psychiatry Research·Sarah K Francazio, Christopher A Flessner
Jan 16, 2015·Journal of Anxiety Disorders·Elen C B OliveiraJon E Grant
Jul 16, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Borwin BandelowPeter Riederer
Mar 23, 2013·Journal of Psychopharmacology·Samuel R Chamberlain, Trevor W Robbins
Jun 30, 2015·The Journal of Nervous and Mental Disease·Christopher A FlessnerElle Brennan
Mar 22, 2019·The Australian and New Zealand Journal of Psychiatry·Zoe JenkinsDavid Castle
Apr 23, 2019·Scandinavian Journal of Psychology·Christina GallinatAstrid Müller
Jun 26, 2010·The American Journal of Drug and Alcohol Abuse·Brian L Odlaug, Jon E Grant
Aug 16, 2017·Journal of Health Psychology·Suzy Anderson, Victoria Clarke
Feb 6, 2017·The Psychiatric Quarterly·Austin W BlumJon E Grant
Mar 10, 2015·Harvard Review of Psychiatry·Yvonne H C Yau, Marc N Potenza
Apr 3, 2018·Journal of Obsessive-compulsive and Related Disorders·Gregory S Berlin, Han-Joo Lee
Apr 4, 2021·Pharmaceutics·Priusha RavipatiKarine Andrieux
Dec 1, 2010·Current Opinion in Psychiatry

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