Motor Learning and the Cerebellum

Cold Spring Harbor Perspectives in Biology
Chris I De Zeeuw, Michiel M Ten Brinke

Abstract

Although our ability to store semantic declarative information can nowadays be readily surpassed by that of simple personal computers, our ability to learn and express procedural memories still outperforms that of supercomputers controlling the most advanced robots. To a large extent, our procedural memories are formed in the cerebellum, which embodies more than two-thirds of all neurons in our brain. In this review, we will focus on the emerging view that different modules of the cerebellum use different encoding schemes to form and express their respective memories. More specifically, zebrin-positive zones in the cerebellum, such as those controlling adaptation of the vestibulo-ocular reflex, appear to predominantly form their memories by potentiation mechanisms and express their memories via rate coding, whereas zebrin-negative zones, such as those controlling eyeblink conditioning, appear to predominantly form their memories by suppression mechanisms and express their memories in part by temporal coding using rebound bursting. Together, the different types of modules offer a rich repertoire to acquire and control sensorimotor processes with specific challenges in the spatiotemporal domain.

Citations

Dec 15, 2015·Cell Reports·Michiel M ten BrinkeChris I De Zeeuw
Nov 17, 2016·PloS One·Cathrin B CantoChris I De Zeeuw
Nov 3, 2016·Scientific Reports·Aleksandra BaduraChris I De Zeeuw
Jun 7, 2017·The Journal of Physiology·Kai VogesChris I De Zeeuw
Nov 2, 2018·The Journal of Physiology·Maya KonoMichisuke Yuzaki
Dec 12, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Martin J HerrmannBodo Warrings
Feb 3, 2018·Nature Communications·Devika NarainMehrdad Jazayeri
May 6, 2020·The FEBS Journal·Gen OhtsukiAkitoshi Ozaki
Mar 18, 2016·Journal of Neurophysiology·Polina A EgorovaIlya B Bezprozvanny
Mar 4, 2019·The Cerebellum·Pavel FilipMartin Bareš
Jun 6, 2019·The Cerebellum·Lauren N MiterkoRoy V Sillitoe
Feb 10, 2017·Frontiers in Neurology·Angel Batuecas-CaletrioNicolas Perez-Fernandez
Aug 16, 2018·Molecular Psychiatry·Catherine A FrenchChris I De Zeeuw
Mar 30, 2019·Nature Reviews. Neuroscience·Aaron SathyanesanVittorio Gallo
Dec 13, 2019·Journal of Applied Physiology·Kaleen M LavinMarcas M Bamman
Nov 4, 2017·Nature Communications·Pamela ValnegriAzad Bonni
Aug 15, 2018·Nature Communications·Aaron SathyanesanVittorio Gallo
Aug 18, 2018·Neurochemical Research·J PickfordZ I Bashir
Mar 16, 2017·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Florence LabrellGeorges Dellatolas

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