Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion

Journal of Gastroenterology and Hepatology
R HeddleL A Houghton

Abstract

The aim of this study was to define better the motor phenomena associated with the slowing of gastric emptying by a duodenal lipid infusion. Antral, pyloric and duodenal motility were recorded in 10 healthy subjects with a manometric assembly which incorporated multiple perfused side-holes and a sleeve sensor positioned astride the pylorus. The gastric emptying of a standard solid meal and the distribution of the ingesta between the proximal and distal stomach were monitored with a radionuclide technique. A triglyceride emulsion was infused into the duodenum for 45 min once 25% of the meal had emptied. The infusion caused significant slowing in the rate of gastric emptying (P less than 0.01). This slowing in gastric emptying was associated with the suppression of pressure waves in the distal antrum (P less than 0.01) and proximal duodenum (P less than 0.01), the induction of pressure waves isolated to a narrow pyloric segment (P less than 0.01), and a redistribution of ingesta from the distal to proximal stomach. These findings suggest that pressure waves isolated to the pylorus, changes in the intragastric distribution of ingested food, and changes in proximal duodenal motility may all act in concert with changes in antral mot...Continue Reading

References

Jul 1, 1987·American Industrial Hygiene Association Journal·A M JohnstonJ H Vincent
Jan 1, 1988·The British Journal of Radiology·P J CollinsB E Chatterton
Dec 1, 1983·European Journal of Clinical Investigation·S Hannibal, S J Rune
Oct 1, 1984·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·O KeinkeH J Ehrlein
Dec 1, 1983·Gut·C M WhiteJ Alexander-Williams
Oct 1, 1983·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·O Keinke, H J Ehrlein
Jun 1, 1984·Digestive Diseases and Sciences·J G MooreN Alazraki
Sep 1, 1947·The American Journal of Physiology·J H ANNEGERS, A C IVY

❮ Previous
Next ❯

Citations

Jun 1, 1993·Digestive Diseases and Sciences·A M AggarwalG M Thomforde
Aug 1, 1988·Digestive Diseases and Sciences·J A ParaskevopoulosN W Read
Nov 1, 1994·Digestive Diseases and Sciences·L BeniniM Porrini
May 1, 1996·Digestive Diseases and Sciences·K IwakiriY Nakagawa
Feb 17, 1997·Journal of the Autonomic Nervous System·S Homma
Oct 31, 2000·Nutrition·C MacIntoshI M Chapman
Jan 14, 2009·The British Journal of Nutrition·Caroline HaboldHugues Oudart
Mar 15, 2011·The British Journal of Nutrition·Kamilia TaiIan M Chapman
Aug 4, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I M BrennanC Feinle-Bisset
Aug 5, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Deirdre O'DonovanKaren Louise Jones
Jun 2, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Diana GentilcoreKaren L Jones
Jul 2, 1998·Bioscience, Biotechnology, and Biochemistry·Y NagaoT Fushiki
May 5, 2010·World Journal of Gastroenterology : WJG·Nam Q NguyenRichard H Holloway
Dec 3, 2014·Best Practice & Research. Clinical Gastroenterology·Gerald Holtmann, Nicholas J Talley
Dec 7, 2013·Journal of Gastroenterology·Fernando AzpirozJan Tack
Dec 1, 1994·Digestive Diseases and Sciences·M HorowitzG Hebbard
Dec 1, 1994·Digestive Diseases and Sciences·D L WingateC Kreiss
Jan 15, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael Camilleri
Mar 2, 2011·Progress in Lipid Research·Jessica E StewartRussell S J Keast
May 23, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P KuoC K Rayner
Oct 30, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y W MinP-L Rhee
Jun 16, 2015·Physiology & Behavior·Stephen J KentishAmanda J Page
Mar 22, 2006·Physiology & Behavior·Sibylle OeschChristoph Beglinger
Jul 22, 2015·Clinics in Geriatric Medicine·Stijn SoenenKaren L Jones

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