Motor nerve conduction studies on children with spinal muscular atrophy

Acta Paediatrica Japonica; Overseas Edition
Y MiyanomaeT Sawada

Abstract

Median and posterior tibial motor nerve conduction studies were performed on 10 children with spinal muscular atrophy (SMA). Three patients with SMA type I, in whom rapid deterioration occurred, showed reduced motor nerve conduction velocity and a remarkably low M-wave amplitude in both nerves. In type II and III patients, the motor nerve conduction velocity was normal in the median nerve, although the M-wave amplitude was small in the tibial nerve. In four patients, a reduction of the M-wave amplitude was observed as clinical symptoms advanced. These findings may suggest that motor conduction studies in spinal muscular atrophy provide complementary information for understanding the pathogenesis and are also useful to clarify the heterogeneity of this disease.

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Citations

Apr 20, 2012·Brain & Development·Takahiro YonekawaMasayuki Sasaki
Jul 31, 2003·Journal of Child Neurology·Fawzia Cheliout-HerautBrigitte Estournet-Mathiaud

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