Motor neuron disease in a patient with a monoclonal IgMk directed against GM1, GD1b, and high-molecular-weight neural-specific glycoproteins

Annals of Neurology
E Nobile-OrazioG Scarlato

Abstract

In a patient with motor neuron disease and benign IgMk monoclonal gammopathy, the M protein reacted with the glycolipids GM1, GD1b, and asialo GM1 and, by immunoblot, with some high-molecular-weight neural-specific glycoproteins. The main reactive bands had an approximate molecular weight of 250 and 400 kd, were most concentrated in the spinal cord, and were also bound by the lectin peanut agglutinin. The presence of the Ga1(beta 1-3)Ga1NAc epitope on these neural-specific glycoproteins may help to explain the selective neurological impairment of the patient.

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Citations

Jun 1, 1992·Annals of Neurology·N Latov
Oct 1, 1992·Journal of Neurology·M WellerH Wiethölter
Jun 1, 1992·Journal of the Neurological Sciences·E Nobile-OrazioG Scarlato
Dec 1, 1993·Journal of the Neurological Sciences·T Heiman-PattersonM E Shy
Sep 1, 1994·Journal of Neuroimmunology·E Nobile-OrazioG Scarlato
Mar 1, 1994·Journal of Neuroimmunology·R K MizutamariG A Nores
Oct 19, 1994·Biochimica Et Biophysica Acta·B VenerandoG Tettamanti
Apr 30, 1998·Journal of the Neurological Sciences·M CarpoE Nobile-Orazio
Jun 22, 1999·Journal of Neuroimmunology·B CavannaE Nobile-Orazio
Jan 3, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I Niebroj-DoboszH Kwieciñski
Jan 16, 1993·BMJ : British Medical Journal·G Doria, G Tettamanti
Jun 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·E Nobile-Orazio
Feb 13, 2016·Molecular Neurobiology·Sandro SonninoMassimo Aureli
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·E Nobile-OrazioN Meucci
Oct 5, 2007·Journal of the Neurological Sciences·Eduardo Nobile-OrazioMarinella Carpo
Mar 17, 2005·Muscle & Nerve·Eduardo Nobile-OrazioAlberto Priori
Jul 1, 2011·Journal of the Peripheral Nervous System : JPNS·Eduardo Nobile-Orazio, Claudia Giannotta
Apr 26, 2005·Lancet Neurology·Jan-Thies H Van AsseldonkLeonard H Van den Berg

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