Motor recovery and axonal plasticity with short-term amphetamine after stroke

Stroke; a Journal of Cerebral Circulation
Catherine M PapadopoulosWilliam A Wolf

Abstract

There is considerable debate regarding the efficacy of amphetamine to facilitate motor recovery after stroke or experimental brain injury. Different drug dosing and timing schedules and differing physical rehabilitation strategies may contribute to outcome variability. The present study was designed to ascertain (1) whether short-term amphetamine could induce long-term functional motor recovery in rats after an ischemic lesion modeling stroke in humans; (2) how different levels of physical rehabilitation interact with amphetamine to enhance forelimb-related functional outcome; and (3) whether motor improvement was associated with axonal sprouting from intact corticoefferent pathways originating in the contralesional forelimb motor cortex. After permanent middle cerebral artery occlusion, rats received vehicle or amphetamine during the first postoperative week (2 mg/kg, subcutaneously on Postoperative Days 2, 5, and 8). In both treatment groups, separate cohorts of rats were exposed to different levels of "physical rehabilitation" represented by a control environment, enriched environment, or enriched environment with additional sessions of focused activity. Skilled forelimb performance was assessed using the forelimb reaching t...Continue Reading

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Related Concepts

Brain Injuries
Biochemical Pathway
Amphetamine
Infarction, Middle Cerebral Artery
Bulla
Neurons
Middle Cerebral Artery Syndrome
Amphetamine Drug Class Measurement
Neuronal Plasticity
Acute Cerebrovascular Accidents

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