Motor System Pathology in Psychosis

Current Psychiatry Reports
Sebastian Walther, Vijay A Mittal

Abstract

Motor abnormalities are an intrinsic feature of psychosis. Neurological soft signs, Parkinsonism, dyskinesia, and other motor phenomena are frequently observed in subjects at clinical or genetic risk for psychosis as well as first-episode patients, chronic patients. Here, we review the most recent literature on motor assessments and pathophysiology in psychosis. Instrumental measures of fine motor performance, balance, spontaneous motor activity, and gesture indicated motor abnormalities in subjects at risk and across stages of schizophrenia. Motor phenomena are associated with distinct symptom dimensions and may indicate poor outcomes. Neuroimaging studies demonstrated altered neural maturation within critical motor networks in subjects at risk. Furthermore, specific categories of motor dysfunction were associated with distinct structural and functional alterations in the motor system in schizophrenia. Motor abnormalities provide a unique window into the pathobiology of psychosis and have the potential to guide screening, staging, and outcome prediction.

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Citations

Oct 17, 2018·Psychological Medicine·S WaltherS A Shankman
Aug 23, 2019·European Archives of Psychiatry and Clinical Neuroscience·Katherine S F DammeVijay A Mittal
Sep 16, 2019·Current Psychiatry Reports·Emily LipnerLauren M Ellman
May 10, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Erik BootAnne S Bassett
Jun 17, 2020·Expert Review of Neurotherapeutics·Stephanie LefebvreSebastian Walther
Oct 16, 2018·Clinical Psychological Science : a Journal of the Association for Psychological Science·Derek J DeanVijay A Mittal
Oct 31, 2018·Schizophrenia Bulletin·Deborah ApthorpWilliam P Hetrick
Jan 20, 2021·PloS One·Valentina PrestaGiuliana Gobbi
Jan 27, 2021·Schizophrenia Research·Amanda R BolbeckerWilliam P Hetrick
Jan 26, 2021·Frontiers in Psychology·Anastasia Pavlidou, Sebastian Walther
Oct 26, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sebastian WaltherStephan Bohlhalter
May 4, 2021·Schizophrenia Bulletin·Dusan HirjakRobert Christian Wolf
May 9, 2021·Schizophrenia Bulletin·Tina GuptaVijay A Mittal
Jun 10, 2021·Journal of Affective Disorders·Anastasia PavlidouSebastian Walther
Jun 20, 2021·Scandinavian Journal of Psychology·Áron HorváthAttila Szabo
Jun 16, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Francesco Luciano DonatiFabio Ferrarelli
Aug 7, 2021·Schizophrenia Bulletin·Petra Verena ViherSebastian Walther
Apr 17, 2019·Neuropsychobiology·Manuel MorrensSebastian Walther

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