Motor unit involvement in spastic paresis. Relationship between leg muscle activation and histochemistry

Journal of the Neurological Sciences
V DietzJ Quintern

Abstract

In 4 patients with spastic hemiparesis the electromyograms (EMG) of leg muscles were recorded during walking and the gastrocnemius medialis on both sides was investigated by histochemistry and morphometry. During walking a reciprocal mode of muscle activation was preserved on the spastic side, but the EMG amplitude was reduced. In one patient the discharge behaviour of single motor units was investigated during stance. The mean discharge rate on both the spastic and the unaffected side amounted to about 5.5 Hz. Modification of this rate over a wider range by manoeuvres of the trunk was only observed on the unaffected side. Histochemistry and morphometry of the spastic muscle revealed: Increased levels of muscle fibre atrophy (especially type II); A predominance of type I fibres during later stages, when spasticity was established; Structural changes, such as the appearance of target fibres, mainly in type I fibres. These results suggest that the low level of tonic activation in spastic muscle develops tension enough during the stance phase of gait to support the body. The histopathological profile of the spastic gastrocnemius muscle is considered to be indicative of denervation, due to the combined effects of an impaired supras...Continue Reading

References

Nov 1, 1985·Electroencephalography and Clinical Neurophysiology·W BergerV Dietz
Jan 1, 1973·Journal of the Neurological Sciences·M A JohnsonD Appleton
Aug 20, 1966·Nature·V Dubowitz
Apr 1, 1973·Journal of Neurology, Neurosurgery, and Psychiatry·A J McComasN Aguilera
Jan 1, 1974·Biochemical and Biophysical Research Communications·F A Sréter, J Gergely
Jun 1, 1982·Journal of the Neurological Sciences·J L Young, R F Mayer
Aug 1, 1981·Journal of the Neurological Sciences·R S StaronR S Hikida

❮ Previous
Next ❯

Citations

Jan 19, 2006·Experimental Brain Research·Daniel S Marigold, Janice J Eng
Sep 1, 1991·Journal of the Neurological Sciences·F JakobssonL E Thornell
May 9, 2003·Archives of Physical Medicine and Rehabilitation·Olivier Rémy-NérisBernard Bussel
Sep 26, 1997·Electroencephalography and Clinical Neurophysiology·V Dietz
Jun 24, 2000·Journal of the Neurological Sciences·C G CanningN J O'Dwyer
May 29, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·F PisanoR Colombo
Aug 7, 2010·Brain : a Journal of Neurology·Satoko KoganemaruKazuhisa Domen
Jan 1, 2005·Neuromodulation : Journal of the International Neuromodulation Society·Jens Bo NielsenThomas Sinkjaer
Jan 7, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A-K WelmerD K Sommerfeld
Feb 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·A F ThilmannH F Ross
Dec 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·P MarqueC F Roques
May 22, 2009·Journal of Neurophysiology·Catherine E LangJustin A Beebe
Feb 29, 2008·Journal of Neuroengineering and Rehabilitation·Mehdi M MirbagheriWilliam Z Rymer
Feb 29, 2008·Journal of Neuroengineering and Rehabilitation·Trisha M KesarStuart A Binder-Macleod
Jan 28, 2010·Archives of Physical Medicine and Rehabilitation·Astrid M HorstmanArnold de Haan
Jul 24, 2008·Topics in Stroke Rehabilitation·Sang Pak, Carolynn Patten
May 16, 2009·Topics in Stroke Rehabilitation·Julie Vaughan GrahamSheena Irwin-Carruthers
Mar 22, 2008·Clinical Physiology and Functional Imaging·Astrid M HorstmanArnold de Haan
Jun 29, 2004·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Joseph M Hidler, Brian D Schmit
Dec 5, 2006·Archives of Physical Medicine and Rehabilitation·Lori L Ploutz-SnyderMargaret Turk
Dec 11, 2002·Archives of Physical Medicine and Rehabilitation·Alice S RyanRichard F Macko
Jul 1, 1989·IEEE Transactions on Bio-medical Engineering·A StefanovskaR Acimović-Janezic
Dec 1, 1996·IEEE Transactions on Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·J J DalyC Kantor
Aug 22, 2007·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Isabella CampaniniDario Farina
Apr 30, 2004·Muscle & Nerve·Richard L LieberHank Chambers
Jan 9, 2016·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Angelique N Mulder-BrouwerCaroline H Bastiaenen
Jun 18, 2003·Muscle & Nerve·Patrick H McCreaAntony J Hodgson
Oct 12, 2010·Muscle & Nerve·Laura A C Kallenberg, Hermie J Hermens
Mar 20, 1998·Stroke; a Journal of Cerebral Circulation·D A Brown, S A Kautz
Feb 17, 2005·Muscle & Nerve·Jean-Michel Gracies
Mar 16, 2007·Developmental Medicine and Child Neurology·Russell MacgregorDavid Young
Oct 3, 2002·Nature Reviews. Neuroscience·Volker Dietz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.