Motoric cognitive risk syndrome and incident dementia in older adults from the Québec NuAge cohort.

Age and Ageing
Olivier BeauchetGilles Allali

Abstract

The co-occurrence of slow walking speed and subjective cognitive complaint (SCC) in non-demented individuals defines motoric cognitive risk syndrome (MCR), which is a pre-dementia stage. There is no information on the association between MCR and incident dementia in Québec's older population. The study aims to examine the association of MCR and its individual components (i.e. SCC and slow walking speed) with incident dementia in community-dwelling older adults living in the province of Québec (Canada). Québec older people population-based observational cohort study with 3 years of follow-up. Community dwellings. A subset of participants (n = 1,098) in 'Nutrition as a determinant of successful aging: The Québec longitudinal study' (NuAge). At baseline, participants with MCR were identified. Incident dementia was measured at annual follow-up visits using the Modified Mini-Mental State (≤79/100) test and Instrumental Activity Daily Living scale (≤6/8) score values. The prevalence of MCR was 4.2% at baseline and the overall incidence of dementia was 3.6%. MCR (Hazard Ratio (HR) = 5.18, with 95% confidence interval (CI) = [2.43-11.03] and P ≤ 0.001) and SCC alone (HR = 2.54, with 95% CI = [1.33-4.85] and P = 0.005) were associated w...Continue Reading

References

Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Jul 3, 1999·Journal of Clinical Epidemiology·R A WashburnR A Boileau
Sep 19, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joe VergheseRoee Holtzer
Jul 5, 2015·American Journal of Alzheimer's Disease and Other Dementias·Marcelo D MendonçaPaulo Bugalho
Feb 9, 2016·Journal of the American Medical Directors Association·Olivier BeauchetGilles Allali
Dec 9, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Minghui QuanKa He
Jul 4, 2018·Journal of Alzheimer's Disease : JAD·Olivier BeauchetUNKNOWN Canadian Gait Consortium

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