MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice

Frontiers in Behavioral Neuroscience
Elísabet Bello-ArroyoMaría Victoria Gómez-Gaviro

Abstract

Animal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual evaluation and the high costs of automated analysis software. To overcome these limitations, we describe here a new, open source toolbox for ImageJ, called Mouse Behavioral Analysis Toolbox (MouBeAT), designed to analyze different behavioral tests in rodents semi-automatically. These tests include Open Field (OF), Elevated Plus Maze (EPM), Y-maze (YM) test and Morris Water Maze (MWM). MouBeAT showed a high correlation with manual evaluation in all the parameters analyzed for all the behavioral tests, reinforcing its value as an accurate analysis tool. This new tool is freely available online.

References

Jan 31, 1966·Annals of the New York Academy of Sciences·J M Prewitt, M L Mendelsohn
Aug 20, 1984·The Journal of Comparative Neurology·V Chan-PalayS L Palay
Oct 10, 2001·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·L P NoldusR A Tegelenbosch
Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Robert Lalonde
Apr 5, 2002·Neuropsychologia·Stephan HamannFelicia C Goldstein
Jul 23, 2005·The Biochemical Journal·Peter Van Meer, Jacob Raber
May 17, 2006·Journal of Neuroscience Methods·Adriano B L TortDiogo R Lara
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Apr 5, 2007·Nature Protocols·Alicia A Walf, Cheryl A Frye
Feb 18, 2010·Behavior Research Methods·Jonathan B Freeman, Nalini Ambady
Sep 30, 2010·Nature Neuroscience·Eric J Nestler, Steven E Hyman
Dec 25, 2010·Journal of Neuroscience Methods·Raquel da Silva AragãoRaul Manhães-de-Castro
Aug 3, 2011·Journal of Visualized Experiments : JoVE·Kelley Bromley-BritsWeihong Song
Dec 30, 2011·Computers in Biology and Medicine·Carlos Fernando Crispim JuniorJosé Marino-Neto
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Dec 4, 2012·Nature Methods·Mayank KabraKristin Branson
Mar 19, 2014·Journal of Visualized Experiments : JoVE·Hirotaka ShojiTsuyoshi Miyakawa
Jun 2, 2014·Nature Methods·Alfonso Pérez-EscuderoGonzalo G de Polavieja
Oct 24, 2014·Frontiers in Behavioral Neuroscience·Tapan P PatelDavid F Meaney
Jan 20, 2016·The Journal of Clinical Investigation·Katherine L PossinSteven Finkbeiner
Feb 16, 2016·Biological Psychiatry·Nora WalzPaul Pauli
Apr 20, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Raquel Santos-ToscanoAlejandro Higuera-Matas
Jul 21, 2016·Scientific Reports·Mian PengZhongcong Xie
Sep 17, 2016·PLoS Computational Biology·Sheldon L ReevesAnnalisa Scimemi
Sep 22, 2017·Clinical Interventions in Aging·Devin WahlDavid G Le Couteur
Dec 1, 2017·BioTechniques·Sudheer K TungturHiroshi Nishimune

❮ Previous
Next ❯

Citations

Oct 8, 2020·Animal Models and Experimental Medicine·Bharata Regmi, Manoj K Shah
Jun 1, 2021·Computers in Biology and Medicine·Kyle M Hatton-JonesEugene F du Toit
Jul 15, 2021·Nature Communications·Sourav K BoseWilliam H Peranteau
Nov 16, 2021·Frontiers in Behavioral Neuroscience·Guanglong SunXinjian Li

❮ Previous
Next ❯

Software Mentioned

VideoTrack
FFmpeg
Linux
MATLAB
Mouse Behavioral Analysis Toolbox ( MouBeAT )
AnyMaze
Toolbox
Ethovision
Windows
OF

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.