Mouse alloantibodies capable of blocking cytotoxic T cell function. II. Further study on the relationship between the blocking antibodies and the products of the Lyt-2 locus

European Journal of Immunology
N ShinoharaD H Sachs

Abstract

The specificity of mouse alloantibodies which blocked allogeneic killer cells has been confirmed as Ly-2.2 using B6 X C3H recombinant inbred (RI) strains. All of the RI strains tested were sensitive to the cell-mediated lymphocytotoxicity (CML)-blocking effect of our C3H anti-B 10.BR antisera and also carried the Lyt-2b allele. This result and studies using Lyt-2-congenic strains firmly localized the genes encoding the target antigen of CML-blocking antibodies in or near the Lyt-2 locus. In addition, a monoclonal anti-Lyt-2.2 antibody was found to block the CML reaction of B6 killer cells, but not that of B6 Ly-2.1 killers. Blocking antibodies to one allele blocked killing by Lyt-2-heterozygous F1 killer cells, but the inhibition curve reached a plateau at a significantly lower level than that seen on the killer cells of the sensitive parent. Our results thus suggest that Lyt-2 antigens are of functional significance on killer T cells, but do not reveal whether or not that significance involves the T cell receptor.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E NakayamaL J Old
Jan 1, 1977·Contemporary Topics in Molecular Immunology·A K Kimura, H Wigzell
Jun 11, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E A BoyseL J Old

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Citations

Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T W ChangG Goldstein
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D DavignonT A Springer
Apr 1, 1984·The Journal of Experimental Medicine·J L GreensteinS J Burakoff
Jul 1, 1985·The Journal of Experimental Medicine·J L GreensteinS J Burakoff
Jan 1, 1983·Immunological Reviews·B BonavidaH Wexler

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