Mouse anesthesia and analgesia

Current Protocols in Mouse Biology
Sean Adams, Cholawat Pacharinsak

Abstract

Providing anesthesia and analgesia for mouse subjects is a common and critical practice in the laboratory setting. These practices are necessary for performing invasive procedures, achieving prolonged immobility for sensitive imaging modalities (magnetic resonance imaging for instance), and providing intra- and post-procedural pain relief. In addition to facilitating the procedures performed by the investigator, the provision of anesthesia and analgesia is crucial for the preservation of animal welfare and for humane treatment of animals used in research. Furthermore, anesthesia and analgesia are important components of animal use protocols reviewed by Institutional Animal Care and Use Committees, requiring careful consideration and planning for the particular animal model. In this article, we provide technical outlines for the investigator covering the provision of anesthesia by two routes (injectable and inhalant), guidelines for monitoring anesthesia, current techniques for recognition of pain, and considerations for administering preventative analgesia.

References

Nov 1, 1993·Anesthesia and Analgesia·H Kehlet, J B Dahl
Jan 1, 1993·Methods in Enzymology·P A Flecknell
Aug 14, 2002·British Journal of Anaesthesia·A Scholz
Jul 1, 1997·International Journal of Obstetric Anesthesia·F M Gamlin, G Lyons
Mar 30, 2005·Brain Research. Brain Research Protocols·Marco WeiergräberToni Schneider
Dec 7, 2006·Biology Letters·Naomi Cappuccino, David Carpenter
Apr 19, 2007·Clinical and Experimental Pharmacology & Physiology·Qi XuXiao-Jun Du
Mar 24, 2009·Research in Veterinary Science·Matthew C LeachPaul A Flecknell
Jun 19, 2009·Laboratory Animals·Amy L DickinsonPaul A Flecknell
May 11, 2010·Nature Methods·Dale J LangfordJeffrey S Mogil
Feb 3, 2011·Cold Spring Harbor Protocols·Andrew J EwaldMikala Egeblad
Apr 12, 2011·Current Opinion in Anaesthesiology·Jørgen B Dahl, Henrik Kehlet

❮ Previous
Next ❯

Citations

Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyMarielle Scherrer-Crosbie
Jun 13, 2015·Current Protocols in Mouse Biology·Cheryl L Ackert-BicknellLuanne L Peters
Jun 20, 2017·Current Protocols in Mouse Biology·Alexis RapinNicola L Harris
Mar 3, 2017·Current Protocols in Mouse Biology·Pedro M QuirosJohan Auwerx
Mar 3, 2017·Current Protocols in Mouse Biology·Raffaella Maria GadaletaAntonio Moschetta
Mar 3, 2017·Current Protocols in Mouse Biology·Zhiyong ZhangGuirong Wang
Dec 19, 2019·Current Protocols in Toxicology·Cynthia GuilbertKoren K Mann
Sep 5, 2019·Current Protocols in Immunology·Przemysław BłyszczukOliver Distler
May 30, 2020·Journal of Molecular Neuroscience : MN·Lina ZhangLi Huang
Feb 25, 2021·Current Protocols·Briana I Martinez, Sarah E Stabenfeldt
Jun 29, 2021·ILAR Journal·Kaela L NavarroCholawat Pacharinsak
Sep 3, 2021·Scientific Reports·Javier Jimenez-MartinRuth M Empson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Environmental Science & Technology
Laboratory Animal Science
J A Will, A Gendron-Fitzpatrick
© 2022 Meta ULC. All rights reserved