PMID: 11908755Mar 23, 2002Paper

Mouse anxiety: the power of knockout

The Pharmacogenomics Journal
K P Lesch

Abstract

The role of the neurokinine 1 receptors (NK1R) and its endogenous ligand, the neuropeptide substance P (SP) in the pathophysiology and treatment response of anxiety and depression has been controversial. In a new study, however, mice with a targeted inactivation of the NK1R show a phenotype that is associated with anxiety-related behaviors and stress responses. Since this behavioral phenotype was associated with an increase in serotonergic function, NK1R knockout mice represent a systematic model for advanced investigations of SP/NK1R and serotonin system interaction in anxiety responses. The availability of an increasing number of knockout mouse anxiety models as well as integration of emerging tools and technologies for genetic analysis will provide the groundwork for the genetic dissection of anxiety and related disorders.

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Citations

Nov 19, 2003·European Journal of Pharmacology·Klaus Peter LeschLise Gutknecht
Jun 26, 2004·Annual Review of Neuroscience·Joshua A Gordon, Rene Hen
Jan 4, 2012·Human Psychopharmacology·Ruihua Hou, David S Baldwin
May 9, 2009·Biological Psychiatry·Elena AkimovaSiegfried Kasper
Oct 5, 2011·Pharmacology, Biochemistry, and Behavior·Kathleen E Morrison, Matthew A Cooper
Sep 25, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Christine MiaskowskiBradley E Aouizerat
Mar 31, 2015·Journal of Abnormal Child Psychology·Gemma ReynoldsChris Askew

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