Mouse bioassay for in vivo screening of oestrogen and progesterone antagonists

Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine
J Skarda, E Köhlerová

Abstract

This study tested and compared the anti-proliferative and proliferative activities of two anti-oestrogens and three anti-progestins on four separate mouse model systems: young intact and adult ovariectomized (OV-X) females, and young intact and adult castrated males. Pure steroidal anti-oestrogen ICI 182,780 (ICI) decreased mammary and uterine growth stimulated by endogenous hormones in young intact females and by exogenous hormones [progesterone (Prog), 17beta-oestradiol (E) or E plus Prog] in both young intact and adult ovariectomized (OV-X) females. Non-steroidal anti-oestrogen EM-800 (EM), on the other hand, had no effect on mammary and uterine growth stimulated by endogenous hormones in young intact females and in adult OV-X females. Uterine growth was even stimulated by EM alone, and a combination of EM plus Prog not only stimulated uterine growth but also mammary growth (an oestrogenic agonistic activity). However, EM showed anti-oestrogenic activities in both mammary and uterine tissues in females treated with E or E plus Prog. In males, ICI and EM decreased mammary growth stimulated by exogenous hormones (E or E plus Prog) in both young intact and adult castrated animals. In young intact, but not in adult castrated mal...Continue Reading

References

Mar 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·H MichnaM F el Etreby
Jan 1, 1989·Journal of Steroid Biochemistry·D PhilibertL Nédélec
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
Apr 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·J A TaylorM W Wang
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·F S vom SaalW V Welshons
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·F LabrieR Veilleux
Jun 14, 2000·Animal Reproduction Science·B Hoffmann, G Schuler
Jun 19, 2001·Molecular and Cellular Endocrinology·R A HessJ Bahr
Jul 18, 2001·The Journal of Steroid Biochemistry and Molecular Biology·J A RobertsonN H Ing
May 2, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Michaela LuconiElisabetta Baldi
Mar 22, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Georg SagerCatharina Engström
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Caroline M MarkeyCarlos Sonnenschein
Sep 2, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·J Skarda
Aug 19, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·E Köhlerová, J Skarda

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Citations

Jan 26, 2013·Reproductive Toxicology·Laura N VandenbergAna M Soto
Jul 15, 2015·Toxicology·Nathália Orlandini CostaDaniela Cristina Ceccatto Gerardin
Mar 11, 2017·Environmental Health : a Global Access Science Source·SriDurgaDevi KollaLaura N Vandenberg

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