Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages.

Journal of Leukocyte Biology
Jordi SintesP Engel

Abstract

CD84 is 1 of the 9 SLAM family cell-surface receptors involved in leukocyte activation. The CD84 ectodomain is highly glycosylated, and its cytoplasmic tail contains 2 copies of an ITSM, which can be phosphorylated. Here, we report that although mouse CD84 was present on all BM HSCs, its expression declined in developing thymic and BM lymphocytes. However, CD84 expression levels did increase significantly during the later maturation stages and were expressed abundantly on mature B and T cells. Among lymphocyte subsets, the highest expression was found on innate-like lymphocytes; specifically, on NKT and marginal zone B cells. Splenic CD4+ T(FH) cells exhibited higher levels of CD84 compared with the other CD4+ T cell subsets. CD84 was expressed abundantly on monocytes, macrophages, granulocytes, and DCs. Moreover, as the function of CD84 in myeloid cells remains unknown, we focused on the role this receptor plays in mouse macrophage activation. Transfection of CD84 in RAW-264.7 macrophages led to an increase in MAPK phosphorylation and NF-κB activation upon LPS stimulation. Concomitantly, the presence of CD84 increased the LPS-induced secretion of TNF-α and MCP-1 but lowered IL-10 and IL-6 production significantly. This modulat...Continue Reading

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Citations

Nov 26, 2010·Immunology and Cell Biology·Jordi Sintes, Pablo Engel
Jan 12, 2011·Annual Review of Immunology·Jennifer L CannonsPamela L Schwartzberg
Feb 3, 2016·Frontiers in Immunology·Boaz Job van DrielCox Terhorst
Mar 26, 2016·Frontiers in Immunology·Nicholas J CollettiMichael H Shaw
Aug 27, 2016·The British Journal of Dermatology·J M P A van den ReekE M G J de Jong
Oct 22, 2017·Stem Cells and Development·Eva Christine SchumacherDieter Häussinger
Nov 13, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei CaiCongfeng Xu
Dec 14, 2018·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marta CuencaPablo Engel

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