Mouse embryonic submandibular gland epithelium loses its tissue integrity during early branching morphogenesis

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Yohki HiedaY Nakanishi

Abstract

During the development of the mouse submandibular gland, the epithelium undergoes not only shape changes to produce extensively branched lobules and stalk, but also changes in cell arrangement from a cell mass to a cavitated cell sheet. The present study examined the organization in the developing epithelium of intercellular adhesion systems and of actin-containing microfilaments. E-cadherin and beta-catenin, which are components of cell-to-cell adherens junctions in epithelial cells, were distributed along the cell periphery of almost the entire epithelium of the submandibular gland at all stages examined and were mainly localized at the apical region of the oral epithelium. Actin-containing microfilaments, which are associated with cell-to-cell adherens junctions, showed a distribution similar to that of those molecules. In contrast, although the distributions of desmoplakins I/II, major desmosomal proteins, and ZO-1 (a tight junction protein) were seen in the oral epithelium and proximal stalk of the submandibular gland epithelium, signals representing these molecules were absent from or much reduced in the submandibular gland epithelium of the cell mass at the 12- and 13-day stages. In the 14-day gland, they strongly appear...Continue Reading

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Citations

Sep 21, 2007·BMC Developmental Biology·Heena PanchalBeatrice Howard
Dec 17, 2009·BMC Developmental Biology·Anne-Christine HickChristophe E Pierreux
Jun 3, 2010·BMC Developmental Biology·Barbara VerstraetenAnn Huysseune
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Janice L WalkerMaria A Kukuruzinska
Jun 20, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jeff C HsuKenneth M Yamada
Sep 5, 2014·Journal of Tissue Engineering and Regenerative Medicine·Noel J LeighOlga J Baker
Aug 19, 2006·Differentiation; Research in Biological Diversity·Vaishali N PatelMatthew P Hoffman
Aug 28, 2014·Developmental Cell·Pavel I NedvetskySarah M Knox
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Aug 3, 2011·Developmental Biology·Nisha PatelIsabelle Miletich
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Jul 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A Sue MenkoMaria A Kukuruzinska
Sep 15, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Atsushi HashizumeYohki Hieda
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Aug 3, 2006·Journal of Cell Science·Melinda LarsenKenneth M Yamada

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