Feb 1, 1976

Mouse epidermal aryl hydrocarbon hydroxylase

The Journal of Investigative Dermatology
S Thompson, T J Slaga

Abstract

Mouse skin contains a NADPH-dependent, aryl hydrocarbon hydroxylase (AHH), which is inducible by polycyclic aromatic hydrocarbons. In general, unsubstituted polycyclic hydrocarbons caused a greater induction of epidermal AHH than substituted one (1,2,3,4-dibenzanthracene greater than 1,2,5,6-dibenzanthracene greater than benz (a)anthracene equal 3-methylcholanthrene greater than 7,12-dimethlbenz (a)anthracene) which did not correlate with their ability to initiate tumors in mouse skin. Two different techniques were used to isolate epidermis and similar results were obtained with both. However, the technique of isolating epidermis using a mild heat treatment required that the temperature be maintained at 52 degrees C for 30 sec. If the temperature was raised to 54 degrees C or above, there was a large reduction in the AHH activity. Isolated epidermis has 4 to 5 times the AHH activity as dermis and about twice that of whole skin. This was true for control mice or mice in which AHH was induced by pretreatment with benz(a)anthracene.

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Mentioned in this Paper

20-Methylcholanthrene
Benz(a)Anthracenes
Polycyclic Hydrocarbons, Aromatic
Benzanthracene
Dermis
Methylcholanthrene
Cytochrome P-450 CYP1A2
Neoplasms
Anthracene
Xenobiotic Monooxygenases

About this Paper

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