PMID: 37377Mar 1, 1979

Mouse erythropoietic stem cell lines function normally 100 months: loss related to number of transplantations

Mechanisms of Ageing and Development
D E Harrison

Abstract

Marrow stem cell lines from old and young donors in parallel experiments were transplanted into genetically anemic W/WV recipients. These recipients were populated and their anemias were cured by stem cell lines from WCB6F1 or C57BL/6 dorons that had been repeatedly transplanted up to five times at annual intervals into successive W/WV recipients. Old marrow cell lines produced erythrocytes normally for as long as 2600 to 3000 days. However, after three to four serial transplantations many stem cell lines failed to cure at least two-thirds of the recipients, and all failed by transplantation six. This decline occurred in a similar pattern whether the original stem line donor was old or young. Two experiments suggested that the decline was caused by the transplantation procedure: (1) chromosomally marked donor cells from old and young donors permanently populated lymph nodes in lethally irradiated recipients after the first transplantation, but under the same conditions cell lines from the same donors transplanted a second time were substantially infiltrated by regenerating recipient cells; (2) the ability to compete with the same chromosomally marked cell line in populating irradiated recipients declined markedly in both old an...Continue Reading

References

Oct 6, 2007·Stem Cell Reviews·S M Chambers, Margaret A Goodell
Apr 28, 2011·International Journal of Hematology·Jichun Chen
Mar 1, 1979·Mechanisms of Ageing and Development·D E Harrison
Mar 1, 1982·Mechanisms of Ageing and Development·Y GozesN Trainin
Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·Ilaria Bellantuono
Dec 10, 2003·Experimental Hematology·Karen LipovskyJichun Chen
Jun 11, 1998·Mechanisms of Ageing and Development·Yoko HirabayashiT Inoue
May 26, 1999·Experimental Hematology·J ChenD E Harrison
Apr 27, 2000·Experimental Hematology·J ChenD E Harrison
Nov 13, 2008·Cytotechnology·Andrew D ClarkTessa L Holyoake
Jun 15, 2010·Experimental Aging Research·Ingeborg StelzerKonrad Schauenstein
Aug 14, 2013·Rejuvenation Research·Jaime Font de Mora, Antonio Díez Juan
Jul 1, 1989·Environmental Health Perspectives·E P CronkiteJ E Bullis
Oct 7, 2005·International Journal of Hematology·Jichun Chen
Jun 15, 2011·Current Opinion in Immunology·Carolien M WoolthuisGerwin Huls
Dec 26, 2009·Experimental Gerontology·Aysegul V Ergen, Margaret A Goodell
Jun 9, 2009·Current Opinion in Immunology·Amanda Waterstrat, Gary Van Zant
Apr 7, 2009·Biochimica Et Biophysica Acta·Alexander Y Maslov, Jan Vijg
Feb 4, 2006·Stem Cells·Leonie M Kamminga, G de Haan
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·John Tower
Oct 23, 2008·Biochemical Pharmacology·Yoko Hirabayashi, Tohru Inoue
Aug 1, 2006·The American Journal of Pathology·David BryderIrving L Weissman
Feb 26, 2008·Cell·Derrick J RossiIrving L Weissman
May 16, 2008·Mechanisms of Ageing and Development·Luigi A Warren, Derrick J Rossi
Sep 28, 2014·Experimental Cell Research·Isabel Beerman, Derrick J Rossi
Oct 25, 2016·Leukemia·J J JungG de Haan
Jan 12, 2017·Stem Cell Reports·David J H F KnappConnie J Eaves
Nov 13, 2004·Experimental Hematology·Jichun Chen
Jan 7, 2016·Development·Michael B Schultz, David A Sinclair
Aug 25, 2007·Nature Reviews. Molecular Cell Biology·Norman E Sharpless, Ronald A DePinho
Apr 19, 2012·Neural Computation·Ryan C Kelly, Robert E Kass
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Renee V GardnerLily Leiva
Jul 3, 2002·Experimental Biology and Medicine·Yoko HirabayashiTohru Inoue

Citations

May 1, 1978·The Journal of Experimental Medicine·D E HarrisonJ A Delaittre
Mar 1, 1979·Mechanisms of Ageing and Development·D E Harrison
May 1, 1975·Journal of Gerontology·D E Harrison
Aug 1, 1974·Experimental Gerontology·G Silini, U Ansreozzi
May 1, 1968·Archives of Biochemistry and Biophysics·E S Russell, S E Bernstein

Related Concepts

Colony-Forming Units, Hematopoietic
C57BL/6 Mouse
Erythropoiesis
Senility
Etiology
Lymph Nodes
Infiltration
Cell Division Phases
Specimen Type - Erythrocytes
Erythroid Progenitor Cells

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