Mouse Fgf8-Cre-LacZ lineage analysis defines the territory of the postnatal mammalian isthmus

The Journal of Comparative Neurology
Charles WatsonL Puelles

Abstract

The isthmus is recognized as the most rostral segment of the hindbrain in non-mammalian vertebrates. In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. We attempted to find if the region of early embryonic Fgf8 expression (which is considered to involve the entire extent of the prospective isthmus initially) might help to identify the boundaries of the isthmus in postnatal animals. By creating an Fgf8-Cre-LacZ lineage in mice, we were able to show that Fgf8-Cre reporter expression in postnatal mice is present in the same nuclei that characterize the isthmic region in birds. The 'signature' isthmic structures in birds include the trochlear nucleus, the dorsal raphe nucleus, the microcellular tegmental nuclei, the pedunculotegmental nucleus, the vermis of the cerebellum, rostral parts of the parabrachial complex and locus coeruleus, and the caudal parts of the substantia nigra and VTA. We found that all of these structures were labeled with the Fgf8-Cre reporter in the mouse brain, and we conclude that the isthmus is a distinct segment of th...Continue Reading

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Citations

Apr 18, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Luis PuellesMargaret Martínez-de-la-Torre
Apr 27, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Carmen Díaz, Luis Puelles
May 4, 2017·Journal of Neuroscience Research·Margaret Martinez-de-la-TorreLuis Puelles
Apr 17, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·José Luis Ferran, Luis Puelles
Apr 6, 2019·Nature Reviews. Neuroscience·Benjamin W OkatySusan M Dymecki
Aug 27, 2019·Frontiers in Neuroanatomy·Hans J Ten Donkelaar, Luis Puelles
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Simone Macrì, Nicolas Di-Poï
Nov 22, 2020·The Journal of Comparative Neurology·Herminio M GuajardoKathryn G Commons
Dec 23, 2021·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Takahiro Ota, Masaki Komiyama

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