PMID: 6169669Jun 15, 1981Paper

Mouse fibroblasts transformed by Rous sarcoma virus express a virus-specific non-virion transplantation antigen

International Journal of Cancer. Journal International Du Cancer
M PratP M Comoglio

Abstract

Rous sarcoma virus (RSV)-transformed fibroblasts from different animals species a serologically detectable virus-induced non-virion cell surface antigen (VCSA), whose expression is controlled by the transforming viral src gene and by a cellular gene. Now, by in vivo immunization, we have found that RSV-transformed fibroblasts from different mouse strains share a virus-specific transplantation antigen. In fact, only animals immunized with irradiated syngeneic or allogeneic fibroblasts transformed by RSV, but not animals immunized with cells transformed by different oncogenic agents, rejected a lethal dose of syngeneic RSV-induced tumor cells. Immunoprecipitation tests with monospecific antisera showed that the expression of this antigen did not correlate with the presence of intracellular viral proteins other than the src gene product pp60src. However, hyperimmunization of mice with hamster or quail fibroblasts transformed by RSV, that express a high level of pp60src, did not induce transplantation resistance. It is concluded that the expression of both the serologically-defined VCSA and the transplantation antigen is the result of the interaction of pp60src with host cell gene product(s) rather than the simple exposure of pp60s...Continue Reading

References

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Citations

Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M PratS Landolfo
Sep 30, 1991·International Journal of Cancer. Journal International Du Cancer·S WalterA Mantovani
Jun 15, 1983·International Journal of Cancer. Journal International Du Cancer·M PratP M Comoglio
Apr 15, 1982·International Journal of Cancer. Journal International Du Cancer·R FerraciniP M Comoglio

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