Mouse forepaw lumbrical muscles are resistant to age-related declines in force production

Experimental Gerontology
Katelyn A RussellChristopher L Mendias

Abstract

A progressive loss of skeletal muscle mass and force generating capacity occurs with aging. Mice are commonly used in the study of aging-associated changes in muscle size and strength, with most models of aging demonstrating 15-35% reductions in muscle mass, cross-sectional area (CSA), maximum isometric force production (Po) and specific force (sPo), which is Po/CSA. The lumbrical muscle of the mouse forepaw is exceptionally small, with corresponding short diffusion distances that make it ideal for in vitro pharmacological studies and measurements of contractile properties. However, the aging-associated changes in lumbrical function have not previously been reported. To address this, we tested the hypothesis that compared to adult (12month old) mice, the forepaw lumbrical muscles of old (30month old) mice exhibit aging-related declines in size and force production similar to those observed in larger limb muscles. We found that the forepaw lumbricals were composed exclusively of fibers with type II myosin heavy chain isoforms, and that the muscles accumulated connective tissue with aging. There were no differences in the number of fibers per whole-muscle cross-section or in muscle fiber CSA. The whole muscle CSA in old mice was ...Continue Reading

References

Oct 1, 1988·The Journal of Physiology·S V Brooks, J A Faulkner
Jun 7, 2005·Experimental Gerontology·Esther E Dupont-Versteegden
May 20, 2006·Journal of Applied Physiology·Christopher L MendiasJohn A Faulkner
May 20, 2006·Journal of Applied Physiology·Erik P Rader, John A Faulkner
Jun 27, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nicole C Lockhart, Susan V Brooks
May 23, 2008·American Journal of Physiology. Cell Physiology·Rainer NgJohn A Faulkner
Jan 13, 2011·The Journal of Physiology·Krishnan S RamaswamyJohn A Faulkner
Jul 21, 2012·Endocrine·Jonathan P Gumucio, Christopher L Mendias
Apr 16, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ted G GraberLaDora V Thompson
Aug 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Darcée D Sloboda, Susan V Brooks
Jul 6, 2014·Journal of Applied Physiology·Lauren K WoodSusan V Brooks

❮ Previous
Next ❯

Citations

Jul 28, 2016·Journal of Muscle Research and Cell Motility·Feng PanYong-Jun Rui
Jun 14, 2020·Journal of Anatomy·Aleksandra M MechJames N Sleigh
Jul 25, 2020·Cell Death & Disease·James N SleighGiampietro Schiavo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Emidio E PistilliJeffrey H Wimsatt
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Jeffrey J WidrickDena P Garner
© 2021 Meta ULC. All rights reserved