Mouse genetic models of cleft lip with or without cleft palate

Birth Defects Research. Part A, Clinical and Molecular Teratology
Diana M Juriloff, Muriel J Harris

Abstract

Nonsyndromic cleft lip and palate (CLP) is among the most common human birth defects. Transmission patterns suggest that the causes are "multifactorial" combinations of genetic and nongenetic factors, mostly distinct from those causing cleft secondary palate (CP). The major etiological factors are largely unknown, and the embryological mechanisms are not well understood. In contrast to CP or neural tube defects (NTD), CLP is uncommon in mouse mutants. Fourteen known mutants or strains express CLP, often as part of a severe syndrome, whereas nonsyndromic CLP is found in two conditional mutants and in two multifactorial models based on a hypomorphic variant with an epigenetic factor. This pattern suggests that human nonsyndromic CLP is likely caused by regulatory and hypomorphic gene variants, and may also involve epigenetics. The developmental pathogenic mechanism varies among mutants and includes deficiencies of growth of the medial, lateral or maxillary facial prominences, defects in the fusion process itself, and shifted midline position of the medial prominences. Several CLP mutants also have NTD, suggesting potential genetic overlap of the traits in humans. The mutants may reflect two interacting sets of genetic signaling p...Continue Reading

References

Jan 1, 1979·American Journal of Medical Genetics·M Vekemans, F C Fraser
Jan 1, 1992·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·V M Diewert, K Y Wang
Feb 1, 1990·The Journal of Experimental Zoology·J D McNeishW J Scott
Dec 1, 1971·American Journal of Epidemiology·S Hay
Jun 1, 1970·Journal of Medical Genetics·F C Fraser, H Pashayan
Jan 1, 1969·British Medical Bulletin·C O Carter
Jun 1, 1969·Genetical Research·D R Johnson
Feb 1, 1963·Developmental Biology·D G Trasler, F C Fraser
May 1, 1982·The American Journal of Anatomy·G MillicovskyM C Johnston
Apr 1, 1980·Teratology·D M Juriloff, F C Fraser
Mar 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K Y WangM Y Kuo
Jan 1, 1997·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·A C LidralW Magee
Feb 1, 1997·British Journal of Obstetrics and Gynaecology·G C SmithJ E Fleming
Oct 23, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M HargraveP Koopman
May 1, 1998·Teratology·F C Fraser, A Gwyn
May 1, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K Y WangM Y Kuo
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·T NottoliT Williams

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Citations

Jun 8, 2013·ILAR Journal·Ratnam S SeelanRobert M Greene
Apr 16, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Robert J LipinskiWade Bushman
Mar 3, 2011·Plastic and Reconstructive Surgery·Benjamin LeviMichael T Longaker
Apr 29, 2010·The Journal of Clinical Investigation·Helen A ThomasonJill Dixon
May 7, 2011·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Fedik RahimovJeffrey C Murray
Aug 3, 2011·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Yunus BuyuJaphet Gilyoma
Jul 4, 2012·International Journal of Environmental Research and Public Health·Awny NaimPaola Manduca
Apr 10, 2013·Epigenomics·Ratnam S SeelanRobert M Greene
Jun 19, 2012·Annual Review of Genomics and Human Genetics·Mary L Marazita
Feb 26, 2013·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Antonius J M LuijsterburgChristl Vermeij-Keers
Aug 26, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Nesrine Z MostafaReena Talwar
Mar 13, 2014·Clinics in Plastic Surgery·Stephanie E WatkinsArthur S Aylsworth
Aug 6, 2011·European Journal of Pharmacology·Amy L InselmanJim Kaput
Oct 28, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M C Buser, H R Pohl
Oct 8, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ferhat OzturkAli Nawshad
Jul 9, 2009·Oral Diseases·A JugessurN Kilpatrick
Dec 11, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Edward J Caterson, Stephanie A Caterson
Aug 8, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Ariadne LetraAlexandre R Vieira
Apr 5, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Ratnam S SeelanRobert M Greene
Apr 12, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Eloisa CartaPhilip Stanier
Jan 13, 2011·Genesis : the Journal of Genetics and Development·Viktoria AndreevaPamela C Yelick
Mar 9, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jenna A PlamondonDiana M Juriloff
Aug 14, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Joshua F RobinsonElaine M Faustman
Jun 12, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Joshua F RobinsonElaine M Faustman
Jun 15, 2010·Birth Defects Research. Part C, Embryo Today : Reviews·Robert M Greene, M Michele Pisano
Jul 1, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Partha MukhopadhyayRobert M Greene
Mar 6, 2010·Congenital Anomalies·Toshiaki WatanabeToru Fukui
Sep 27, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Diana M JuriloffLiane Gagnier
Nov 12, 2013·Congenital Anomalies·Yasunori SasakiTaku Fujiwara
Aug 29, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Ariadne LetraJacqueline T Hecht
Feb 4, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yue HanYongchu Pan
Nov 26, 2009·American Journal of Medical Genetics. Part a·Elisabeth MangoldAmalia Diaz Lacava
Mar 10, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Robert J LipinskiIan J Rowland
Jul 16, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Claudio R CortésCarol Wicking
Apr 29, 2014·European Journal of Medical Genetics·Núria Setó-Salvia, Philip Stanier
Jul 1, 2008·Mechanisms of Development·Wai-Yee LiVesa Kaartinen
Jul 19, 2008·Developmental Biology·Helen A ThomasonJill Dixon

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