Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells

Virology
Jun ZuoCornelia C Bergmann

Abstract

Infection by the neurotropic JHM strain of mouse hepatitis virus (JHMV) results in an acute encephalomyelitis associated with demyelination. T cells are critical in controlling viral replication, but also contribute to central nervous system (CNS) pathogenesis. To reveal a role for innate effectors in anti-viral immunity and neurological disease, JHMV pathogenesis was studied in mice deficient in interleukin-15 (IL-15-/-) and natural killer (NK) cells. Clinical disease, CNS inflammation and demyelination in infected IL-15-/- mice were similar to wild-type mice. Despite the absence of NK cells and suboptimal CD8+ T cell responses, IL-15-/- mice controlled JHMV replication as efficiently as wild-type mice. Similar kinetics of class I and class II upregulation on microglia further suggested no role of NK cells in regulating major histocompatibility complex (MHC) molecule expression on resident CNS cells. IL-15 and NK cells thus appear dispensable for anti-viral immunity and CNS pathogenesis during acute JHMV infection.

References

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Citations

May 15, 2012·Future Virology·Brett S MarroThomas E Lane
Oct 6, 2006·Journal of Virology·Mikhail V OvanesovMikhail V Pletnikov
Oct 10, 2008·Journal of Virology·Carine SavarinStephen A Stohlman
Apr 8, 2010·Critical Reviews in Immunology·Thomas E Lane, Martin P Hosking
Dec 31, 2010·Journal of Virology·Timothy W PharesCornelia C Bergmann
Apr 22, 2011·Journal of Virology·Cristina P MarquesCornelia C Bergmann
Dec 25, 2008·Journal of Neuroimmunology·Jun ZuoCornelia C Bergmann
Dec 12, 2012·Virology·Jason G WeingerThomas E Lane
Nov 29, 2014·Frontiers in Oncology·Amanda K HuberDavid N Irani
Aug 16, 2018·Viral Immunology·Dominic SkinnerThomas E Lane
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy W PharesCornelia C Bergmann

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Methods Mentioned

BETA
flow cytometry
ELISA
transgenic
FCS

Software Mentioned

Microplate Manager
CellQuestPro

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