Mouse IgA allotypes have major differences in their hinge regions

Immunogenetics
Julia M Phillips-Quagliata

Abstract

Six IgA allotypes are serologically identifiable in inbred mice. The sequences of the PCR-amplified C alpha 1, C alpha 2 and C alpha 3 exons from the genomic DNA of mice of four previously unsequenced allotypes already have been compared with those of BALB/c and of a wild mouse, Mus pahari, in the literature. Sporadic differences, including several that may encode the known allotypic determinants, are found throughout the three exons, but major differences occur in the hinge. The hinge is longest in DBA/2 ( Igh-2(c)) mice, having an extra codon compared with that of BALB/c ( Igh-2(a)) and B10.A ( Igh-2(b)) mice. It is two codons shorter in CE ( Igh-2(f)) and four shorter in M. pahari, AKR and NZB (both Igh-2(d)) mice, but the position of the missing codons in the latter two strains is offset from that in M. pahari. The hinges in BALB/c ( Igh-2(a)) and DBA/2 ( Igh-2(c)) differ most from each other and from the other three allotypes, which are fairly closely related. Both BALB/c and DBA/2 have O-linked glycosylation sites, but they are in different positions in the hinge. Compared with BALB/c ( Igh-2(a)), B10.A( Igh-2(b)) has two extra Cys residues in the hinge, while DBA/2 ( Igh-2(c)), AKR/NZB ( Igh-2(d)) and CE ( Igh-2(f)) each...Continue Reading

Citations

Jul 19, 2005·Immunogenetics·Huitong ZhouQian Fang
Dec 24, 2011·Journal of the American Society of Nephrology : JASN·Masako OtaniShozo Izui
Jul 17, 2012·Journal of the American Society of Nephrology : JASN·Keiko OkazakiYasuhiko Tomino
Dec 17, 2009·Immunogenetics·Julia M Phillips-Quagliata
Jan 3, 2012·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Urs E NydeggerLorenz Risch
Sep 24, 2004·Immunology·Jenny M Woof, Michael A Kerr
Dec 14, 2005·Developmental and Comparative Immunology·Huitong ZhouQian Fang
Jun 24, 2016·American Journal of Physiology. Renal Physiology·Mary H Foster
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Masao KiharaShozo Izui
Jul 6, 2019·PLoS Neglected Tropical Diseases·Elena LorenteDaniel López
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenneth A RogersRoberta Attanasio

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