Mouse intravenous challenge models and applications

Methods in Molecular Biology
Donna M MacCallum

Abstract

Murine intravenous (IV) challenge models have been widely used in medical mycology to study fungal virulence, host responses, and antifungal efficacy. This chapter describes the well-characterised Candida albicans IV challenge model, where fungal cells are administered directly into the mouse bloodstream to initiate a systemic infection. The preparation of tissue samples from infected mice to allow evaluation of disease progression and host responses is also described.

Citations

Feb 15, 2018·Antimicrobial Agents and Chemotherapy·Karen A O'Hanlon CohrtAnne-Marie Lund Winther
Sep 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Mario D GarciaLuke W Guddat

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