Mouse is the new woman? Translational research in reproductive immunology

Seminars in Immunopathology
David A Clark

Abstract

In an outbred mating typical of human reproduction, the embryo and feto-placental unit express paternal antigens to which the mother's immune system can react. However, the embryo and feto-placental unit can engineer the maternal immune defense system towards helpful rather than harmful reactions. Indeed, this begins with the prospective mother's exposure to paternal seminal plasma. In this review, the pregnancy complications of implantation failure (infertility), recurrent spontaneous abortion, pre-eclampsia and intrauterine growth restriction, and premature labor are examined to determine the degree of similarity between events in women and events in lab mouse models. The artificially induced model of endometriosis (which contributes to infertility) is also compared to what occurs in women. One may conclude that the female mouse provides a good analog of the human female. Nevertheless, it is always important to validate mouse data with human studies. The discussion focuses on the intrauterine interface between embryonic and placental tissues and maternal uterine tissues and the dialogue that is referred to as cross-talk. Issues relating to bidirectional transplacental traffic of immune system cells are not discussed as there ...Continue Reading

References

Dec 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·G W RandallP A Gantt
Jan 1, 1991·Annals of the New York Academy of Sciences·D A ClarkC Harley
Mar 1, 1991·Baillière's Clinical Obstetrics and Gynaecology·R G Lea, D A Clark
Jan 1, 1989·American Journal of Reproductive Immunology : AJRI·D A Clark, G Chaouat
Feb 1, 1987·American Journal of Obstetrics and Gynecology·S Daya
Nov 1, 1983·Journal of Reproductive Immunology·G ChaouatT G Wegmann
Oct 1, 1980·The Journal of Experimental Medicine·E L ParrR S Tulsi
Apr 1, 1993·American Journal of Reproductive Immunology : AJRI·D A ClarkG Chaouat
Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·C B CoulamD A Clark
Mar 1, 1997·American Journal of Reproductive Immunology : AJRI·P C ArckD A Clark
Jun 11, 1999·The New England Journal of Medicine·A J WilcoxC R Weinberg
Jun 23, 1999·American Journal of Reproductive Immunology : AJRI·T YamamotoH Mori
Aug 6, 1999·Journal of Reproduction and Fertility·K WakudaY Noda
Oct 21, 1999·Cellular Immunology·P C ArckD A Clark
Jun 28, 2000·American Journal of Obstetrics and Gynecology·M G GravettD A Eschenbach
Jul 4, 2001·Nature Reviews. Genetics·J Rossant, J C Cross
Sep 29, 2001·Obstetrics and Gynecology·B M FaberC C Coddington
Feb 9, 2002·Gynecologic and Obstetric Investigation·Tomio IwabeNaoki Terakawa
Aug 1, 2002·American Journal of Reproductive Immunology : AJRI·David A ClarkReginald M Gorczynski
Apr 12, 2003·Journal of Assisted Reproduction and Genetics·David A Clark
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ellen M Barber, Jeffrey W Pollard
Jul 12, 2003·American Journal of Reproductive Immunology : AJRI·Ming-Yih Wu, Hong-Nerng Ho
Jul 12, 2003·American Journal of Reproductive Immunology : AJRI·David A ClarkReginald M Gorczynski
Jul 15, 2003·Mediators of Inflammation·Krzysztof SzylloAnna Kamer-Bartosinska
Dec 11, 2003·Bulletin of Experimental Biology and Medicine·V G SafronovaG T Sukhikh
Dec 24, 2003·Human Pathology·Joanne HempstockGraham J Burton
Feb 6, 2004·Nature Immunology·Varuna R AluvihareAlexander G Betz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Reproductive Immunology : AJRI
Sung Ki LeeJoanne Kwak-Kim
Annual Review of Immunology
Adrian Erlebacher
Current Opinion in Obstetrics & Gynecology
Diana Alecsandru, Juan Antonio García-Velasco
© 2022 Meta ULC. All rights reserved