Mouse kidney progenitor cells accelerate renal regeneration and prolong survival after ischemic injury

Stem Cells
Po-Tsang LeeMing-Jer Tang

Abstract

Acute tubular necrosis is followed by regeneration of damaged renal tubular epithelial cells, and renal stem cells are supposed to contribute to this process. The purpose of our study is to test the hypothesis that renal stem cells isolated from adult mouse kidney accelerate renal regeneration via participation in the repair process. A unique population of cells exhibiting characteristics consistent with renal stem cells, mouse kidney progenitor cells (MKPC), was isolated from Myh9 targeted mutant mice. Features of these cells include (1) spindle-shaped morphology, (2) self-renewal of more than 100 passages without evidence of senescence, and (3) expression of Oct-4, Pax-2, Wnt-4, WT-1, vimentin, alpha-smooth muscle actin, CD29, and S100A4 but no SSEA-1, c-kit, or other markers of more differentiated cells. MKPC exhibit plasticity as demonstrated by the ability to differentiate into endothelial cells and osteoblasts in vitro and endothelial cells and tubular epithelial cells in vivo. The origin of the isolated MKPC was from the interstitium of medulla and papilla. Importantly, intrarenal injection of MKPC in mice with ischemic injury rescued renal damage, as manifested by decreases in peak serum urea nitrogen, the infarct zone,...Continue Reading

Citations

Dec 1, 2011·Current Urology Reports·Sargis SedrakyanLaura Perin
Jun 5, 2014·BioMed Research International·Akito MaeshimaYoshihisa Nojima
Aug 18, 2010·Stem Cell Reviews and Reports·Franca AnglaniAngela D'Angelo
Jan 18, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Hsiang ChouShuei-Liong Lin
Mar 24, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Egle PavydeRomaldas Maciulaitis
May 9, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dylan BurgerKevin D Burns
May 22, 2013·Clinical and Translational Medicine·Yue Li, Rebecca A Wingert
Apr 20, 2019·Oxidative Medicine and Cellular Longevity·Monica Maribel Mata-MirandaGustavo Jesus Vazquez-Zapien
Oct 5, 2018·Frontiers in Medicine·David M BurmeisterMichael A Dubick
Dec 19, 2019·International Journal of Molecular Sciences·Nadezda V AndrianovaDmitry B Zorov

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