Mouse lactoferrin gene: a marker for estrogen and epidermal growth factor

Environmental Health Perspectives
C T Teng

Abstract

Lactoferrin mRNA in the 21-day-old mouse uterus can be increased several hundredfold by estrogen. The physiological role of lactoferrin in mouse uterus is unclear; however, it can be a useful marker for the estrogen action in the uterus. The structural organization and the chromosome location of the lactoferrin gene are similar to members of the transferrin gene family. At the 5' flanking region of the lactoferrin gene, we have characterized two modules that respond to estrogen and growth factor stimulation. Each module is composed of either overlapping or multiple transcription factor-binding elements. The well-characterized estrogen and growth factor response modules in the mouse lactoferrin gene could serve as the foundation to understand the intricate molecular mechanisms of estrogen action and its relationship to growth factors.

References

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Citations

Mar 12, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Christina T Teng
Feb 1, 1997·Environmental Health Perspectives·J AshbyG L Randall
Sep 21, 2001·Environmental Health Perspectives·E Padilla-BanksR R Newbold
Sep 11, 2009·Proceedings. Biological Sciences·Jeff R PowellHafiz Maherali
Oct 25, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Manuela I BaderGünter Vollmer
Nov 20, 2014·Nutrition Reviews·Yunlei ZhangLigia R Rodrigues
Sep 6, 2001·Phytotherapy Research : PTR·D M Miller-MartiniY H Wong
Feb 25, 2000·Molecular and Cellular Endocrinology·B D GehmJ L Jameson
Jun 1, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Z MehmoodN G Carmichael

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