PMID: 9427531Jan 14, 1998Paper

Mouse latent TGF-beta binding protein-2: molecular cloning and developmental expression

Biochimica Et Biophysica Acta
J FangJ Bonadio

Abstract

The molecular cloning and developmental expression of mouse LTBP-2 are presented here. We established the identity of the cDNA by sequence comparison (80% identity with human LTBP-2) and by chromosome localization (mouse chromosome 12, band D, a region of conserved synteny with the human LTBP-2 gene). In contrast to LTBP-1 and LTBP-3, mouse LTBP-2 apparently is a more modular protein, with proline/glycine-rich sequences always alternating with clusters of cysteine-rich structural motifs. We found for the first time that LTBP-2 gene expression in mouse embryos was restricted to cartilage perichondrium and blood vessels, a somewhat surprising result since other LTBP genes are widely expressed in rodent tissues. Therefore, mouse LTBP-2 may play a critical role in the assembly of latent TGF-beta complexes in developing elastic tissues such as cartilage and blood vessel.

References

Mar 8, 1991·Cell·E Ruoslahti, Y Yamaguchi
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Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T TsujiT Nakamura
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R S GronkeP A Friedman
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Nov 21, 1996·Biochemical and Biophysical Research Communications·J FangJ Bonadio

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Citations

Apr 1, 2004·Gene Expression Patterns : GEP·Brendan A S McIntyreMiikka Vikkula
Jun 6, 2000·Advanced Drug Delivery Reviews·R J LevyJ Bonadio
Jan 29, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·S SinhaC M Kielty
Dec 6, 2000·The Biochemical Journal·R Oklü, R Hesketh

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