Mouse lines differing in sensitivity to beta-CCM differ in tasks used for testing antidepressants

Pharmacology, Biochemistry, and Behavior
Jean-Claude Do-RegoJean Costentin

Abstract

Two lines of mice, previously selected for their sensitivity (BS) or their resistance (BR) to an anxiogenic benzodiazepine (BZ) receptor inverse agonist, methyl beta-carboline-3-carboxylate (beta-CCM), have recently been shown to present several differences in anxiety. In the present study, attempt was made to extend their behavioral profile in two situations classically used for testing antidepressant drugs. Reassessment of locomotor performance of these new populations confirmed that the motor activity of BR mice was lower than that of BS mice. In both the forced-swimming and the tail suspension tests, the immobility time of BS mice was significantly higher than that of BR mice. In the tail suspension test, two administrations of imipramine (30 mg/kg i.p., 5 h and 30 min before testing) significantly reduced the immobility time of BS mice but not of BR mice. From these data, it appears that BS mice are more "depressed" than BR mice. Thus, these selectively bred lines may represent potentially useful animal models to investigate behavioral, neurochemical and neuroendocrine correlates of antidepressant action.

References

Oct 1, 1978·European Journal of Pharmacology·R D PorsoltM Jalfre
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·M J Raffalli-SebilleR H Dodd
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·L SteruR D Porsolt
Jan 1, 1988·Psychopharmacology·J I Semba, R Takahashi
Jan 6, 1983·Nature·L P Prado de CarvalhoJ Rossier
Aug 17, 1984·European Journal of Pharmacology·L Prado de CarvalhoJ Rossier
Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·R SunalS O Kayaalp
Sep 1, 1993·International Clinical Psychopharmacology·J Angst
Dec 5, 1996·European Journal of Pharmacology·J M VaugeoisJ Costentin
Feb 6, 1998·Psychopharmacology·J M VaugeoisJ Costentin
May 30, 2001·Neuroscience and Biobehavioral Reviews·P Palanza
Mar 1, 2011·Journal of Substance Abuse Treatment·Kane Saxon MortlockTrevor Patrick Crowe

❮ Previous
Next ❯

Citations

Jul 11, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jakub FichnaJean-Claude do Rego
Nov 23, 2006·Depression and Anxiety·Allan V Kalueff, David J Nutt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved