Mouse mammary tumor-like virus is associated with p53 nuclear accumulation and progesterone receptor positivity but not estrogen positivity in human female breast cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Margaret FaedoWilliam D Rawlinson

Abstract

The purpose is to compare the presence of proteins with known associations with breast cancer-progesterone receptor (PgR), estrogen receptor, and p53, with the prevalence of mouse mammary tumor virus (MMTV)-like DNA sequences in human female breast cancers. A cohort of 128 Australian female breast cancers were screened for MMTV-like DNA sequences using PCR. The presence of PgR, estrogen receptor, and nuclear accumulation of p53 protein was assessed in the same samples using immunohistochemical staining. Nuclear accumulation of p53 was significantly more prevalent (P = 0.05) in archival human breast cancers containing MMTV-like DNA sequences. The presence of progesterone receptor was significantly higher in MMTV-positive than MMTV-negative breast cancers (P = 0.01). No correlation between estrogen receptor and MMTV-like DNA sequences was found. MMTV causes breast cancer in mice, and hormones up-regulate expression of virus in mice mammary tissue. It is unknown if this is the case in human breast cancers shown to contain DNA of MMTV-like viruses. The positive association between MMTV-like DNA sequences and PgR indicates hormones and MMTV may play a role in human breast cancer. Mutations of the tumor suppressor gene p53 are common...Continue Reading

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Citations

Jan 26, 2012·Breast Cancer Research and Treatment·Deepti Joshi, Gertrude Case Buehring
Oct 1, 2010·Journal of Clinical Microbiology·Wei-Li HsuShih-Chieh Chang
Sep 8, 2005·Journal of Clinical Microbiology·S C MunroW D Rawlinson
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Jun 22, 2010·Cancer·Beatriz G-T PogoPaul H Levine
Apr 27, 2010·Journal of Medical Virology·Harpreet JohalWilliam D Rawlinson
Apr 18, 2017·Infectious Agents and Cancer·Thar Htet SanAkihiro Matsukawa
Jun 28, 2021·Infectious Agents and Cancer·Fa-Liang WangHong-Chuan Jin

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