Mouse model of human infertility: transient and local inhibition of endometrial STAT-3 activation results in implantation failure

FEBS Letters
Hitomi NakamuraYuji Murata

Abstract

Embryo implantation involves a series of biochemical reactions and its failure is an important therapeutic target of infertility treatment. We established an infertile mouse model using transient and local suppression of signal transducer and activator of transcription-3 (STAT-3) activity by STAT-3 decoy transfer into the uterine cavity during implantation, resulting in <30% implantation. This infertility is caused by suppression of decidualization, which is indispensable for implantation, and independent of progesterone. These conditions may mimic clinically unexplained infertility. Our results suggest that STAT-3 could be a useful target for diagnosis and therapy of human implantation failure.

References

Nov 1, 1987·Journal of Reproduction and Fertility·Y M Huet, S K Dey
Oct 1, 1993·British Journal of Obstetrics and Gynaecology·T C LiI D Cooke
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·K TakedaS Akira
Oct 24, 1998·Journal of Reproductive Immunology·C SimónA Pellicer
May 26, 1999·Molecular Human Reproduction·R GiessM Sendtner
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·J G ChengC L Stewart
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·J R A SherwinA M Sharkey
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·David E Levy, J E Darnell
Jan 17, 2004·American Journal of Reproductive Immunology : AJRI·Hitomi NakamuraYuji Murata
Jul 29, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Chun-Bo TengZeng-Ming Yang
Nov 10, 2004·Fertility and Sterility·Christos CoutifarisUNKNOWN NICHD National Cooperative Reproductive Medicine Network
Nov 10, 2004·Fertility and Sterility·Evan R MyersUNKNOWN NICHD National Cooperative Reproductive Medicine Network
Nov 20, 2004·Obstetrics and Gynecology Clinics of North America·Orhan Bukulmez, Aydin Arici
Jun 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Othman A MohamedDaniel Dufort
Jun 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rob D CatalanoAndrew M Sharkey

❮ Previous
Next ❯

Citations

Oct 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Seema GrewalHelen J Mardon
Sep 18, 2010·Molecular Human Reproduction·G TeklenburgJan J Brosens
Nov 5, 2011·Molecular Human Reproduction·Hitomi NakamuraSarah A Robertson
Aug 13, 2011·The Journal of Reproduction and Development·Jumpei TerakawaEiichi Hondo
May 15, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·D GhoshJayasree Sengupta
Jul 29, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·L MohametS J Kimber
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christine A WhiteEvdokia Dimitriadis
Feb 12, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Anubha JoshiRajesh Kumar Jha
Jan 29, 2016·American Journal of Reproductive Immunology : AJRI·Gracy Xavier Rosario, Colin L Stewart
Dec 15, 2015·American Journal of Reproductive Immunology : AJRI·Renjini A Padmanabhan, Malini Laloraya
Jan 24, 2016·Molecular and Cellular Endocrinology·Sangappa Basanna ChadchanRajesh Kumar Jha
Jan 12, 2010·American Journal of Reproductive Immunology : AJRI·Ramzi R FinanWassim Y Almawi
Jun 4, 2014·The Journal of Obstetrics and Gynaecology Research·Hitomi NakamuraTadashi Kimura
Dec 7, 2013·Expert Review of Vaccines·Rajesh K Naz
Jun 12, 2016·Seminars in Immunopathology·Mayumi MoriJúlia Szekeres-Bartho
Dec 8, 2016·Scientific Reports·Shu-Yun LiZeng-Ming Yang
Mar 22, 2014·Biology of Reproduction·Meghan E BushwayShawn P Murphy
Jul 18, 2014·Biology of Reproduction·Gracy X RosarioColin L Stewart
Sep 25, 2017·Reproduction, Fertility, and Development·Hitomi NakamuraTadashi Kimura
Mar 28, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jae Hee LeeJae-Wook Jeong
Jan 6, 2017·Clinical Reviews in Allergy & Immunology·Jaume Alijotas-ReigJosep Maria Gris
Oct 18, 2018·Human Reproduction·Hitomi NakamuraTadashi Kimura
Jul 18, 2020·Molecular and Cellular Endocrinology·Upendra Kumar SoniRajesh Kumar Jha
May 22, 2020·Molecular and Cellular Endocrinology·M M MilesiJ Varayoud
Oct 31, 2021·Reproductive Biology and Endocrinology : RB&E·Peng-Chao WangZeng-Ming Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.