Mouse models of autoimmune uveitis

Current Pharmaceutical Design
Izabela P Klaska, J V Forrester

Abstract

Uveitis is a sight threatening intraocular inflammation accounting for approximately 10% of blindness worldwide. On the basis of aetiology, disease can be classified as infectious or non-infectious; and by anatomical localization of inflammation as anterior, posterior and panuveitis. Non-infectious uveitis is believed to be autoimmune in nature with Th1 and Th17 cells being identified as the prominent effector cell types. Numerous animal models of autoimmune uveitis were developed contributing to our understanding of this inflammatory condition. The classical peptide-induced experimental autoimmune uveoretinitis (EAU) model resembles human posterior uveitis due to the recurrent/relapsing nature of the disease; while the intraocular inflammation triggered by administration of bacterial lipopolisaccharide (endotoxin-induced uveitis, EIU) mimics closely anterior uveitis. The clinical need for novel, more targeted forms of anti-inflammatory therapy has emerged as currently available therapeutic strategies are associated with a number of adverse effects and intolerance in patients. This review summarises knowledge about existing mouse models of uveitis, discusses mechanisms driving intraocular inflammation and describes possible cus...Continue Reading

Citations

Oct 3, 2015·Expert Opinion on Therapeutic Targets·Dass S Vinay, Byoung S Kwon
Aug 28, 2018·Acta Ophthalmologica·Kripa Shanker KasudhanAnuradha Chakraborti
May 31, 2019·Journal of Tissue Engineering and Regenerative Medicine·Christine MölzerLucia Kuffová
Aug 5, 2016·Retinal Cases & Brief Reports·Michael T Aaberg, Thomas M Aaberg
Feb 12, 2021·Frontiers in Immunology·Christine MölzerJohn V Forrester

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