Mouse models of MMP and TIMP function.

Methods in Molecular Biology
Sean E GillWilliam C Parks

Abstract

As their name implies, matrix metalloproteinases (MMPs) are thought to be responsible for the turnover of connective tissue proteins, a function that is indeed performed by some family members. However, matrix degradation is possibly not the predominant function of these enzymes. Several studies have demonstrated that MMPs also act on a variety of non-matrix extracellular proteins, such as cytokines, chemokines, receptors, junctional proteins, and antimicrobial peptides, to mediate a wide range of biological processes, such as repair, immunity, and angiogenesis. Our understanding of the many, diverse and, at times, unexpected functions of MMPs largely arose from the use of gene-targeted mice. In this chapter, we discuss the phenotypes of some MMP-deficient and TIMP-null mice and strategies and pitfalls in targeted mutagenesis.

Citations

Nov 19, 2011·Journal of the American Society of Nephrology : JASN·Jesús M López-GuisaAllison A Eddy
Apr 10, 2014·Disease Models & Mechanisms·Matthew Giannandrea, William C Parks
Oct 25, 2016·Critical Reviews in Biochemistry and Molecular Biology·Magali de BruynGhislain Opdenakker
Oct 10, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Felicitas L KollerBarbara Fingleton
Jul 1, 2011·Heart Failure Reviews·Linn MooreZamaneh Kassiri
Jul 26, 2011·Journal of Thrombosis and Thrombolysis·K GopalM J Mahesh Kumar
Mar 20, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Valerie ArpinoSean E Gill
Dec 31, 2020·International Journal of Molecular Sciences·M Elizabeth FiniMark R Wilson

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