Mouse models of multiple sclerosis: lost in translation?

Current Pharmaceutical Design
David Baker, Sandra Amor

Abstract

Multiple sclerosis (MS) is a chronic neurological disorder of the central nervous system (CNS) leading to progressive accumulation of neurological deficits arising from recurrent episodes of inflammation, demyelination and neuronal degeneration. While the aetiology of the disease is unknown MS is widely considered to be the result of aberrant T cell and antibody responses to CNS antigens giving rise to the common concept that MS is an autoimmune disease or that there is an autoimmune component in the pathogenesis. This idea has lead to the development of experimental autoimmune encephalomyelitis (EAE) mouse models of MS in which immunisation with CNS antigens induces neurological and pathological signs of disease in mice. In addition to EAE models, injection with neurotropic viruses has been used to examine how infections are implicated in the disease process and how they may generate autoimmune responses in the CNS. Viral models are also crucial to investigate the impact of blocking trafficking of immune responses into the CNS since an emerging side-effect of current immunotherapeutic approaches in MS is the reactivation of viruses within the CNS. To investigate myelin damage and repair in the absence of the adaptive immune re...Continue Reading

Citations

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Aug 14, 2019·Annals of Clinical and Translational Neurology·David BakerSandra Amor
Apr 20, 2021·Frontiers in Immunology·Yunxuan LiXun Zeng
May 1, 2021·Pharmaceuticals·Paweł GriebKonrad Rejdak
Aug 13, 2021·Frontiers in Cellular Neuroscience·Aaron J MoulsonPeggy Assinck
Nov 3, 2021·Clinical and Experimental Immunology·Sandra AmorDavid Owen

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