Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes

ILAR Journal
H IkegamiToshio Ogihara

Abstract

Except for rare subtypes of diabetes, both type 1 and type 2 diabetes are multifactorial diseases in which genetic factors consisting of multiple susceptibility genes and environmental factors contribute to the disease development. Due to complex interaction among multiple susceptibility genes and between genetic and environmental factors, genetic analysis of multifactorial diseases is difficult in humans. Inbred animal models, in which the genetic background is homogeneous and environmental factors can be controlled, are therefore valuable in genetic dissection of multifactorial diseases. We are fortunate to have excellent animal models for both type 1 and type 2 diabetes--the nonobese diabetic (NOD) mouse and the Nagoya-Shibata-Yasuda (NSY) mouse, respectively. Congenic mapping of susceptibility genes for type 1 diabetes in the NOD mouse has revealed that susceptibility initially mapped as a single locus often consists of multiple components on the same chromosome, indicating the importance of congenic mapping in defining genes responsible for polygenic diseases. The NSY mouse is an inbred animal model of type 2 diabetes established from Jcl:ICR, from which the NOD mouse was also derived. We have recently mapped three major l...Continue Reading

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Citations

Jun 29, 2006·ILAR Journal·Nicole Neubauer, Rohit N Kulkarni
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rodolfo José ChaparroYueh-Hsiu Chien
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Dec 26, 2018·International Journal of Endocrinology·Naru BabayaHiroshi Ikegami
Feb 27, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jung Wook HuhMark W Dewhirst
Jan 3, 2021·Current Diabetes Reports·Mireia Ramos-RodríguezLorenzo Pasquali
May 17, 2021·Journal of Diabetes Investigation·Hiroshi IkegamiShinsuke Noso

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