Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback

Neuron
Matthias HeindorfGeorg B Keller

Abstract

Motor cortex (M1) lesions result in motor impairments, yet how M1 contributes to the control of movement remains controversial. To investigate the role of M1 in sensory guided motor coordination, we trained mice to navigate a virtual corridor using a spherical treadmill. This task required directional adjustments through spontaneous turning, while unexpected visual offset perturbations prompted induced turning. We found that M1 is essential for execution and learning of this visually guided task. Turn-selective layer 2/3 and layer 5 pyramidal tract (PT) neuron activation was shaped differentially with learning but scaled linearly with turn acceleration during spontaneous turns. During induced turns, however, layer 2/3 neurons were activated independent of behavioral response, while PT neurons still encoded behavioral response magnitude. Our results are consistent with a role of M1 in the detection of sensory perturbations that result in deviations from intended motor state and the initiation of an appropriate corrective response.

Citations

Oct 28, 2019·Nature Communications·Wolfgang OmlorFritjof Helmchen
Mar 18, 2020·Frontiers in Molecular Neuroscience·Ann-Sofie Bjerre, Lucy M Palmer
Dec 4, 2019·Nature Communications·Josh MerelGreg Wayne
Sep 27, 2020·Current Opinion in Neurobiology·Nuo Li, Thomas D Mrsic-Flogel
Feb 6, 2020·Brain, Behavior, and Immunity·Monokesh K SenPeter J Shortland
Aug 14, 2019·Current Opinion in Physiology·Eiman Azim, Kazuhiko Seki
Jul 3, 2021·Geriatrics·Henk KoppelaarMartin van Warmerdam
Aug 31, 2020·Current Opinion in Physiology·Mark S BlumbergGreta Sokoloff
Jul 26, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Farhan AugustineHarvey S Singer
Aug 19, 2021·The European Journal of Neuroscience·Silvia NataleCornelius T Gross
Jun 27, 2020·Neuron·Shahar LevyJackie Schiller

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