Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders

Annals of the New York Academy of Sciences
Martin E KeckMarianne B Müller

Abstract

In today's psychiatry there is a great deal of interest in the development of compounds with a novel mechanism of action that diverge from the classical catecholaminergic neurotransmitter system targets. Within the last few years, it has become increasingly evident that the neuroendocrine and behavioral phenotypes of mood and anxiety disorders are at least in part mediated by modulation of corticotropin-releasing hormone (CRH) neurocircuitries and that normalization of an altered neurotransmission after treatment may lead to restoration of disease-related changes. Although this concept was originally derived from peripheral hypothalamic-pituitary-adrenocortical (HPA) assessments in depressed patients, central CRH neuropeptidergic circuits other than those driving the peripherally accessible HPA system may be overactive and could be therapeutic targets of antagonist actions. Genetically engineered mice provide a novel and useful tool to study the endogenous mechanisms underlying aberrant behavior and CRH neurocircuitry regulation. The results obtained from conventional and conditional mutant mice indicate that CRH type 1 receptors may be the primary target to which to direct selective nonpeptide compounds. Moreover, beyond the e...Continue Reading

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Citations

May 19, 2005·Neuroscience and Biobehavioral Reviews·Martin E KeckMarianne B Müller
Dec 17, 2009·Molecular Psychiatry·E B Binder, C B Nemeroff
May 19, 2006·Rejuvenation Research·Damaso CrespoRosario Verduga
Dec 2, 2005·Annual Review of Psychology·E D Leonardo, René Hen
Jun 2, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N TrimbleB Greenwood-van Meerveld
Mar 18, 2005·Comptes rendus biologies·Jan M Deussing, Wolfgang Wurst
Nov 28, 2006·Neuroscience and Biobehavioral Reviews·B F P BroekmanF Boer
Apr 4, 2006·Biological Psychiatry·Marianne B Müller, Florian Holsboer
Dec 17, 2014·Neurobiology of Stress·Rita J Valentino, Elisabeth Van Bockstaele

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