PMID: 2111255Feb 1, 1990Paper

Mouse preproacrosin: cDNA sequence, primary structure and postmeiotic expression in spermatogenesis

Differentiation; Research in Biological Diversity
U KlemmW Engel

Abstract

The primary structure of mouse preproacrosin was deduced by nucleotide sequencing of cDNA clones isolated from a mouse testis cDNA library. The largest cDNA, with 1373 bp, consists of a 11-bp 5'untranslated sequence, a 1254-bp open reading frame terminated by a TGA triplet and a 105-bp 3' untranslated end, including one potential polyadenylation signal. The NH2-terminus of the polypeptide contains a hydrophobic 15-amino acid signal peptide. This cleavable signal sequence is followed by 403 amino acids, representing the acrosin light and the heavy chain of 23 and 380 amino acid residues, respectively. The proteolytic active site segments His, Asp and Ser are part of the heavy chain, as well as a proline-rich COOH-terminus, which is not present in any other serine proteinase studied so far. Furthermore the postmeiotic expression of the preproacrosin gene during mouse spermatogenesis was studied.

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Citations

Sep 1, 1996·Molecular Reproduction and Development·A CiereszkoS I Ochkur
Mar 1, 1997·Molecular Reproduction and Development·I M AdhamW Engel
May 15, 1993·The Journal of Experimental Zoology·R M Williams, R Jones
Apr 1, 1992·Molecular Reproduction and Development·K NayerniaW Engel
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·N MizukiM Kasahara
Oct 8, 1991·Biochimica Et Biophysica Acta·U KlemmW Engel
Sep 13, 1994·Biochimica Et Biophysica Acta·R T Richardson, M G O'Rand
Dec 4, 2001·Journal of Reproductive Immunology·Liz Howes, Roy Jones
Jul 1, 1992·European Journal of Biochemistry·M H Vazquez-LevinJ W Gordon
Aug 19, 2005·Molecular and Cellular Biology·Ibrahim M AdhamWolfgang Engel
Jun 8, 2006·Proteomics·Kathryn K SteinDiana G Myles
Apr 12, 2005·European Journal of Cell Biology·Manfred AlsheimerRicardo Benavente
Nov 30, 1990·Biochemical and Biophysical Research Communications·S KashiwabaraT Baba
Feb 24, 2000·Biology of Reproduction·L I FurlongM H Vazquez-Levin
Aug 1, 1993·The Anatomical Record·B E KurthJ C Herr
Jan 1, 1991·DNA Sequence : the Journal of DNA Sequencing and Mapping·H KremlingW Engel

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