Abstract
The clinical course of prostate cancer is grouped into two broad phases. The first phase, which is the growth of the androgen-dependent cancer (AD-Ca) responds well to androgen depletion treatment while the second phase, that could be termed as androgen depletion-independent cancer (ADI-Ca) does not. We used two separate prostate tumors, one AD-Ca and one ADI-Ca from the conditional Pten deletion mouse model to generate from each a pair of cell lines. The AD-Ca cell lines (E2 and E4) and the ADI-Ca cell lines (cE1 and cE2) display bi-allelic deletion at the Pten gene locus, an event which is specific for the prostate epithelium for this mouse model, and a fairly similar level of expression of the androgen receptor (AR). The ADI-Ca cell lines (cE series) grow well in the absence of androgen, display increased AR transcription under androgen-deprived environment, and retain the sensitivity to increased proliferation when androgen is supplemented. The AD-Ca cell lines (E series) grow slowly in the absence of androgen, and, unlike cE cells, do not show increased AR expression when maintained in the absence of androgen. The detection of epithelial cell markers, such as CK8, CK14, CK18 and E-cadherin in the cE series is conforming wi...Continue Reading
References
Jul 4, 1998·The Journal of Biological Chemistry·M E ChenR A Sikes
Mar 7, 2001·Mechanisms of Development·X WuP Roy-Burman
Oct 1, 2003·The Prostate·Adrie van BokhovenM Scott Lucia
Oct 3, 2003·Cancer Cell·Shunyou WangHong Wu
Dec 24, 2003·PLoS Biology·Lloyd C TrotmanPier Paolo Pandolfi
Jan 2, 2004·Nature Medicine·Charlie D ChenCharles L Sawyers
Mar 18, 2004·Cancer Research·Scott B ShappellRobert D Cardiff
Apr 15, 2004·Endocrine Reviews·Cynthia A Heinlein, Chawnshang Chang
May 28, 2004·Endocrine-related Cancer·P Roy-BurmanM B Cohen
Jul 5, 2005·Cancer Research·Xiaoqian MaJan Trapman
Aug 2, 2005·Cancer Biology & Therapy·Pradip Roy-BurmanKenneth J Pienta
Aug 1, 2006·The American Journal of Pathology·Xin YuanSteven P Balk
Aug 17, 2006·Cancer Research·Zongxiang ZhouAlexander Yu Nikitin
Dec 16, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Donna E HanselJonathan I Epstein
Mar 17, 2007·Cancer Research·Katia J BruxvoortBart O Williams
Jun 8, 2007·Cancer Research·Zongxiang ZhouAlexander Yu Nikitin
Jun 19, 2007·Cancer Research·Tatyana IsayevaSelvarangan Ponnazhagan
Jul 10, 2007·Cancer Research·Jing JiaoHong Wu
Aug 3, 2007·Cancer Research·Chun-Peng LiaoPradip Roy-Burman
Oct 12, 2007·The Prostate·Aaron LeiblichIshtiaq Rehman
Jan 1, 2008·Journal of Biomedical Optics·Jinhyang ChoiAlexander Y Nikitin
Oct 24, 2008·Nature·Kevin G LeongWei-Qiang Gao
Nov 18, 2008·European Urology·Helmut Bonkhoff, Richard Berges
Jan 14, 2009·Cancer Prevention Research·Cory Abate-ShenDavid Threadgill
Mar 20, 2009·Journal of the American Society of Nephrology : JASN·Weichun HeYouhua Liu
Sep 2, 2009·Current Genomics·G N Brooke, C L Bevan
Sep 18, 2009·The Prostate·Helmut Bonkhoff, Richard Berges
Oct 3, 2009·The Lancet Oncology·Yu ChenHoward I Scher
Oct 8, 2009·Cancer Research·Kati K WalteringTapio Visakorpi
Nov 11, 2009·The Prostate·Nobuyuki IshikuraYuko Aoki
Citations
Jul 16, 2011·Hormones & Cancer·Chun-Peng LiaoPradip Roy-Burman
Sep 29, 2011·Hormones & Cancer·Minyoung LimPradip Roy-Burman
Jan 27, 2011·PloS One·Joseph H JeongJae U Jung
Jul 30, 2014·PloS One·ShengYu KuRoberto Pili
Jun 2, 2015·Expert Opinion on Drug Discovery·Kenneth C Valkenburg, Kenneth J Pienta
Mar 2, 2013·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Radek FedrKarel Souček
May 25, 2013·Experimental Cell Research·Seung-Keun HongJong-In Park
Mar 1, 2017·Journal of Cellular and Molecular Medicine·Fernando L-LópezRaúl M Luque
Feb 10, 2017·Nature Communications·Yu ZhengDaniel A Haber
Dec 8, 2011·Veterinary Pathology·J E Rehg, J M Ward
Dec 9, 2017·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Šárka ŠimečkováKarel Souček
Jun 22, 2011·Nature Reviews. Urology·Jones T Nauseef, Michael D Henry
Mar 7, 2012·The Journal of Endocrinology·Soo Ok LeeChawnshang Chang
Sep 18, 2013·Endocrine-related Cancer·Linda Kim PhamPradip Roy-Burman
Jul 22, 2015·PloS One·Mengmeng LiangDavid J Mulholland
Jan 1, 2011·Oncology Letters·Reza HakkakSoheila Korourian
Sep 15, 2019·Molecular Oncology·Ben T CopelandJeremy O Jones
Jul 29, 2011·The Prostate·Leigh EllisRoberto Pili
Sep 30, 2015·Oncotarget·Eva SlabákováKarel Soucek
Aug 23, 2018·The Prostate·Petra W van DuijnWytske M van Weerden
Mar 28, 2019·Oncogene·Parthasarathy SeshacharyuluSurinder K Batra
Mar 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yu ZhengDaniel A Haber
Jul 11, 2020·Scientific Reports·Ján RemšíkKarel Souček
Mar 8, 2017·Endocrine-related Cancer·Chun-Peng LiaoMitchell E Gross
Apr 7, 2019·Scientific Reports·Šárka ŠimečkováKarel Souček
Sep 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ren LiuParkash S Gill
Jan 28, 2014·Molecular Cancer Research : MCR·Lauren A GearyPradip Roy-Burman
Apr 4, 2021·International Journal of Molecular Sciences·Alena MickovaJan Bouchal